Atherosclerosis, formerly considered a bland lipid storage disease, actually involves an
ongoing inflammatory response. Recent advances in basic science have established a …

Background Increased levels of the inflammatory biomarker high-sensitivity C-reactive
protein predict cardiovascular events. Since statins lower levels of high-sensitivity C-reactive …

Atherosclerotic cardiovascular disease results in >19 million deaths annually, and coronary
heart disease accounts for the majority of this toll. Despite major advances in treatment of …

Background Inflammation may be important in the pathogenesis of atherothrombosis. We
studied whether inflammation increases the risk of a first thrombotic event and whether …

Background Since inflammation is believed to have a role in the pathogenesis of cardiovascular
events, measurement of markers of inflammation has been proposed as a method to …

Background Experimental and clinical data suggest that reducing inflammation without
affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory …

ContextInflammation is hypothesized to play a role in development of type 2 diabetes
mellitus (DM); however, clinical data addressing this issue are limited.ObjectiveTo determine …

Background Both C-reactive protein and low-density lipoprotein (LDL) cholesterol levels are
elevated in persons at risk for cardiovascular events. However, population-based data …

Atherosclerosis is a chronic disease of the arterial wall, and a leading cause of death and
loss of productive life years worldwide. Research into the disease has led to many compelling …

Prospective data also demonstrate that CRP is a stronger predictor of risk than is low-density
lipoprotein (LDL) cholesterol. In the largest study to date, both the area under the receiver …