PRDM9 is a zinc finger protein that binds DNA at specific locations in the genome where it
trimethylates histone H3 at lysines 4 and 36 at surrounding nucleosomes. During meiosis in …

In many organisms, recombination rates differ between the two sexes. Here we show that in
mice, this is because of a shorter genomic interference distance in females than in males, …

Mammalian meiotic recombination, which preferentially occurs at specialized sites called
hotspots, ensures the orderly segregation of meiotic chromosomes and creates genetic …

A set of 1638 informative SNP markers easily assayed by the Amplifluor genotyping system
were tested in 102 mouse strains, including the majority of the common and wild-derived …

Examining complete gene knockouts within a viable organism can inform on gene function.
We sequenced the exomes of 3222 British adults of Pakistani heritage with high parental …

In many mammals, including humans and mice, the zinc finger histone methyltransferase
PRDM9 performs the first step in meiotic recombination by specifying the locations of hotspots, …

In mammals, genetic recombination during meiosis is limited to a set of 1- to 2-kb regions
termed hotspots. Their locations are predominantly determined by the zinc finger protein …

… This pair-wise comparison excluded two combinations, B6 and WSB, and CAST and PWD,
due to evidence of shared recombination hotspots (PM Petkov personal communication). For …

To identify cells that have the ability to proliferate and differentiate into all epithelial components
of the liver lobule, we isolated fetal liver epithelial cells (FLEC) from ED 14 Fischer (F) …

Among mammals, genetic recombination occurs at highly delimited sites known as recombination
hotspots. They are typically 1–2 kb long and vary as much as a 1,000-fold or more in …