The human genome contains over one million short tandem repeats. Expansion of a subset
of these repeat tracts underlies over fifty human disorders, including common genetic causes …

Protein degradation is an essential cellular function that, when dysregulated or impaired,
can lead to a wide variety of disease states. The two major intracellular protein degradation …

Most neurodegenerative disorders are thought to result primarily from the accumulation of
misfolded proteins, which interfere with protein homeostasis in neurons. For a subset of …

Fragile X-associated tremor ataxia syndrome (FXTAS) results from a CGG repeat expansion
in the 5′ UTR of FMR1. This repeat is thought to elicit toxicity as RNA, yet disease brains …

A repeat expansion in C9ORF72 causes frontotemporal dementia and amyotrophic lateral
sclerosis (c9FTD/ALS). RNA of the expanded repeat (r(GGGGCC) exp ) forms nuclear foci or …

Fragile X syndrome (FXS) is a common inherited cause of mental retardation resulting from
the absence of the fragile X mental retardation protein (FMRP). FMRP is thought to regulate …

Microbial dysbiosis is a colorectal cancer (CRC) hallmark and contributes to inflammation,
tumor growth, and therapy response. Gut microbes signal via metabolites, but how the …

Fragile X-associated tremor/ataxia syndrome (FXTAS) is an inherited neurodegenerative
disorder caused by the expansion of 55–200 CGG repeats in the 5′ UTR of FMR1. These …

Repeat-associated non-AUG (RAN) translation allows for unconventional initiation at
disease-causing repeat expansions. As RAN translation contributes to pathogenesis in multiple …

Fragile X-associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder
caused by a limited expansion of CGG repeats in the 5′ UTR of FMR1. Two mechanisms are …