Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …

Approaches exploiting trait distribution extremes may be used to identify loci associated
with common traits, but it is unknown whether these loci are generalizable to the broader …

Age at menarche is a marker of timing of puberty in females. It varies widely between
individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, …

Atrial fibrillation (AF) affects more than 33 million individuals worldwide 1 and has a complex
heritability 2 . We conducted the largest meta-analysis of genome-wide association studies (…

Background: Few studies have investigated effects of air pollution on the incidence of
cerebrovascular events. Objectives: We assessed the association between long-term exposure to …

To dissect the genetic architecture of blood pressure and assess effects on target organ
damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 …

IgA nephropathy (IgAN), major cause of kidney failure worldwide, is common in Asians,
moderately prevalent in Europeans, and rare in Africans. It is not known if these differences …

Atrial fibrillation affects more than 33 million people worldwide and increases the risk of
stroke, heart failure, and death 1 , 2 . Fourteen genetic loci have been associated with atrial …

Frailty is a common geriatric syndrome and strongly associated with disability, mortality and
hospitalization. Frailty is commonly measured using the frailty index (FI), based on the …

Dogs may be beneficial in reducing cardiovascular risk in their owners by providing social
support and motivation for physical activity. We aimed to investigate the association of dog …