A central challenge in investigating biological phenomena is the development of techniques
to modify genomic DNA with nucleotide precision that can be transmitted through the germ …

The active sites of multisubunit RNA polymerases have a “trigger loop” (TL) that multitasks
in substrate selection, catalysis, and translocation. To dissect the Saccharomyces cerevisiae …

Multisubunit RNA polymerases (msRNAPs) exhibit high sequence and structural homology,
especially within their active sites, which is generally thought to result in msRNAP functional …

Background and Objectives Genetic variants affect both Parkinson disease (PD) risk and
manifestations. Although genetic information is of potential interest to patients and clinicians, …

Escape from nonsense mediated mRNA decay (NMD-) can produce activated or inactivated
gene products, and bias in rates of escape can identify functionally important genes in …

This Research Article reports that lethality was observed for rpb1 E712A and D716K. While
rephenotyping mutants from this study, the authors found that a subclone with a frameshift …

High splitting, optically amplified, passive optical networks (SuperPONs) are investigated in
terms of redundancy provision and protection mechanisms. Options for redundancy, …

Background Studies in animals and an open-label trial have suggested a role for antibodies
to tumor necrosis factor α, specifically chimeric monoclonal antibody cA2, in the treatment of …

Background: The 4-variable Modification of Diet in Renal Disease (4-v MDRD) and
Cockcroft-Gault (CG) equations are commonly used for estimating glomerular filtration rate (GFR); …

Petrol attendants are exposed to petrol volatile organic compounds (VOCs) which may have
genotoxic and carcinogenic effects. The single-cell gel electrophoresis assay (comet assay) …