User profiles for P. J. Smaldino
Philip J SmaldinoBall State University Verified email at bsu.edu Cited by 582 |
Yin Yang 1 contains G-quadruplex structures in its promoter and 5′-UTR and its expression is modulated by G4 resolvase 1
Yin Yang 1 (YY1) is a multifunctional protein with regulatory potential in tumorigenesis. Ample
studies demonstrated the activities of YY1 in regulating gene expression and mediating …
studies demonstrated the activities of YY1 in regulating gene expression and mediating …
Chronic periodontitis− human papillomavirus synergy in base of tongue cancers
…, T Melendy, A Hyland, PJ Smaldino… - … –head & neck …, 2009 - jamanetwork.com
… Drafting of the manuscript: Tezal and Smaldino. Critical revision of the manuscript for
important intellectual content: Sullivan Nasca, Stoler, Melendy, Hyland, Rigual, and Loree. …
important intellectual content: Sullivan Nasca, Stoler, Melendy, Hyland, Rigual, and Loree. …
Transcriptional start site heterogeneity modulates the structure and function of the HIV-1 genome
The promoter in HIV type 1 (HIV-1) proviral DNA contains three sequential guanosines at
the U3–R boundary that have been proposed to function as sites for transcription initiation. …
the U3–R boundary that have been proposed to function as sites for transcription initiation. …
G4 resolvase 1 tightly binds and unwinds unimolecular G4-DNA
B Giri, PJ Smaldino, RG Thys, SD Creacy… - Nucleic acids …, 2011 - academic.oup.com
It has been previously shown that the DHX36 gene product, G4R1/RHAU, tightly binds
tetramolecular G4-DNA with high affinity and resolves these structures into single strands. Here, …
tetramolecular G4-DNA with high affinity and resolves these structures into single strands. Here, …
[HTML][HTML] The RNA helicase DHX36–G4R1 modulates C9orf72 GGGGCC hexanucleotide repeat–associated translation
…, YH Wang, JP Vaughn, PK Todd, PJ Smaldino - Journal of Biological …, 2021 - ASBMB
GGGGCC (G 4 C 2 ) hexanucleotide repeat expansions in the endosomal trafficking gene
C9orf72 are the most common genetic cause of ALS and frontotemporal dementia. Repeat-…
C9orf72 are the most common genetic cause of ALS and frontotemporal dementia. Repeat-…
The cytoplasmic and nuclear populations of the eukaryote tRNA-isopentenyl transferase have distinct functions with implications in human cancer
Mod5 is the yeast tRNA isopentenyl transferase, an enzyme that is conserved from bacteria
to humans. Mod5 is primarily cytoplasmic where it modifies the A37 position of a few tRNAs, …
to humans. Mod5 is primarily cytoplasmic where it modifies the A37 position of a few tRNAs, …
[HTML][HTML] Lipid biosynthesis perturbation impairs endoplasmic reticulum–associated degradation
…, KA Woodruff, JB Olesen, PJ Smaldino… - Journal of Biological …, 2023 - ASBMB
The relationship between lipid homeostasis and protein homeostasis (proteostasis) is
complex and remains incompletely understood. We conducted a screen for genes required for …
complex and remains incompletely understood. We conducted a screen for genes required for …
[HTML][HTML] Mutational Dissection of Telomeric DNA Binding Requirements of G4 Resolvase 1 Shows that G4-Structure and Certain 3'-Tail Sequences Are Sufficient for …
PJ Smaldino, ED Routh, JH Kim, B Giri, SD Creacy… - PLoS …, 2015 - journals.plos.org
Ends of human chromosomes consist of the six nucleotide repeat d[pTTAGGG] n known as
telomeric DNA, which protects chromosomes. We have previously shown that the DHX36 …
telomeric DNA, which protects chromosomes. We have previously shown that the DHX36 …
[HTML][HTML] Differential Gene Expression following DHX36/G4R1 Knockout Is Associated with G-Quadruplex Content and Cancer
…, JP Vaughn, YH Wang, PJ Smaldino… - International Journal of …, 2024 - mdpi.com
G-quadruplexes (G4s) are secondary DNA and RNA structures stabilized by positive cations
in a central channel formed by stacked tetrads of Hoogsteen base-paired guanines. G4s …
in a central channel formed by stacked tetrads of Hoogsteen base-paired guanines. G4s …
The human tRNA-modifying protein, TRIT1, forms amyloid fibers in vitro
TRIT1 is a highly conserved tRNA isopentenyl transferase that modifies a subset of tRNAs
in human cells and is a candidate tumor suppressor in lung cancer in certain ethnic …
in human cells and is a candidate tumor suppressor in lung cancer in certain ethnic …