Shamil Sunyaev and colleagues present exome sequencing methods and their applications
in studies to identify the genetic basis of human complex traits. They include analyses of the …

The outcome after infection with the human immunodeficiency virus type 1 (HIV-1) is a
complex phenotype determined by interactions among the pathogen, the human host and the …

Dendritic cells (DCs) are essential in order to combat invading viruses and trigger antiviral
responses. Paradoxically, in the case of HIV-1, DCs might contribute to viral pathogenesis …

Genome-wide association studies (GWAS) have proven to be a powerful method to identify
common genetic variants contributing to susceptibility to common diseases. Here, we show …

Guanylate binding proteins (GBPs) are an interferon (IFN)-inducible subfamily of guanosine
triphosphatases (GTPases) with well-established activity against intracellular bacteria and …

Human immunodeficiency virus (HIV)–resistant commercial sex workers provide a unique
opportunity to study correlates of protection associated with natural resistance to HIV infection. …

Genome-wide association studies (GWAS) have recently identified KIF1B as susceptibility
locus for hepatitis B virus (HBV)–related hepatocellular carcinoma (HCC). To further identify …

Previous genome-wide association studies (GWAS) of HIV-1–infected populations have been
underpowered to detect common variants with moderate impact on disease outcome and …

… McLaren … Horton, RE, McLaren, PJ, Fowke, K., Kimani, J. & Ball, TB Cohorts for the study of
HIV-1-… McLaren, PJ et al. Association study of common genetic variants and HIV-1 acquisition …

10.7554/eLife.01123.001 HIV-1 sequence diversity is affected by selection pressures arising
from host genomic factors. Using paired human and viral data from 1071 individuals, we …