User profiles for P. G. Ridge
Perry RidgeAssociate Professor of Biology and Neuroscience, Brigham Young University Verified email at byu.edu Cited by 7888 |
[HTML][HTML] Genetics of Alzheimer's disease
Alzheimer’s disease is the most common form of dementia and is the only top 10 cause of
death in the United States that lacks disease-altering treatments. It is a complex disorder with …
death in the United States that lacks disease-altering treatments. It is a complex disorder with …
Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease
… Cell lysates were extracted in non-ionic detergent, analysed by SDS–PAGE and immunoblot
with antibodies to the Myc-tag on APP (9E10) or β-tubulin. Middle (Aβ42) and right (Aβ40) …
with antibodies to the Myc-tag on APP (9E10) or β-tubulin. Middle (Aβ42) and right (Aβ40) …
[HTML][HTML] Alzheimer's disease: analyzing the missing heritability
Alzheimer’s disease (AD) is a complex disorder influenced by environmental and genetic
factors. Recent work has identified 11 AD markers in 10 loci. We used Genome-wide Complex …
factors. Recent work has identified 11 AD markers in 10 loci. We used Genome-wide Complex …
[HTML][HTML] Composition and evolution of the vertebrate and mammalian selenoproteomes
M Mariotti, PG Ridge, Y Zhang, AV Lobanov… - PloS one, 2012 - journals.plos.org
Background Selenium is an essential trace element in mammals due to its presence in proteins
in the form of selenocysteine (Sec). Human genome codes for 25 Sec-containing protein …
in the form of selenocysteine (Sec). Human genome codes for 25 Sec-containing protein …
[HTML][HTML] Assessment of the genetic variance of late-onset Alzheimer's disease
Alzheimer's disease (AD) is a complex genetic disorder with no effective treatments. More
than 20 common markers have been identified, which are associated with AD. Recently, …
than 20 common markers have been identified, which are associated with AD. Recently, …
[PDF][PDF] Germline mutations in NFKB2 implicate the noncanonical NF-κB pathway in the pathogenesis of common variable immunodeficiency
Common variable immunodeficiency (CVID) is a heterogeneous disorder characterized by
antibody deficiency, poor humoral response to antigens, and recurrent infections. To …
antibody deficiency, poor humoral response to antigens, and recurrent infections. To …
RAB10: an Alzheimer's disease resilience locus and potential drug target
Alzheimer’s disease (AD) is mainly a late-onset neurodegenerative disorder. Substantial
efforts have been made to solve the complex genetic architecture of AD as a means to identify …
efforts have been made to solve the complex genetic architecture of AD as a means to identify …
[HTML][HTML] Comparative genomic analyses of copper transporters and cuproproteomes reveal evolutionary dynamics of copper utilization and its link to oxygen
PG Ridge, Y Zhang, VN Gladyshev - PLoS One, 2008 - journals.plos.org
Copper is an essential trace element in many organisms and is utilized in all domains of life.
It is often used as a cofactor of redox proteins, but is also a toxic metal ion. Intracellular …
It is often used as a cofactor of redox proteins, but is also a toxic metal ion. Intracellular …
[HTML][HTML] Mitochondria and Alzheimer's disease: the role of mitochondrial genetic variation
… In contrast to Ridge et al., Maruszak et al. [37] (dataset described above) reported U5A1 as
… In the same two studies just discussed, Ridge et al. [45] reported K1A1B or K1A1B2A1 as risk …
… In the same two studies just discussed, Ridge et al. [45] reported K1A1B or K1A1B2A1 as risk …
[HTML][HTML] Evaluating the necessity of PCR duplicate removal from next-generation sequencing data and a comparison of approaches
Background Analyzing next-generation sequencing data is difficult because datasets are
large, second generation sequencing platforms have high error rates, and because each …
large, second generation sequencing platforms have high error rates, and because each …