User profiles for P. F. Vale
Pedro ValeInstitute of Ecology and Evolution, University of Edinburgh Verified email at ed.ac.uk Cited by 2058 |
Beyond killing: can we find new ways to manage infection?
The antibiotic pipeline is running dry and infectious disease remains a major threat to public
health. An efficient strategy to stay ahead of rapidly adapting pathogens should include …
health. An efficient strategy to stay ahead of rapidly adapting pathogens should include …
CRISPR-mediated phage resistance and the ghost of coevolution past
The past is never dead. It's not even past William Faulkner (1951) Bacteria can acquire heritable
immunity to viral (phage) enemies by incorporating phage DNA into their own genome. …
immunity to viral (phage) enemies by incorporating phage DNA into their own genome. …
[HTML][HTML] Co-infection alters population dynamics of infectious disease
Co-infections by multiple pathogen strains are common in the wild. Theory predicts co-infections
to have major consequences for both within- and between-host disease dynamics, but …
to have major consequences for both within- and between-host disease dynamics, but …
How are arbovirus vectors able to tolerate infection?
One of the defining features of mosquito vectors of arboviruses such as Dengue and Zika is
their ability to tolerate high levels of virus proliferation without suffering significant pathology. …
their ability to tolerate high levels of virus proliferation without suffering significant pathology. …
Costs of CRISPR-Cas-mediated resistance in Streptococcus thermophilus
PF Vale, G Lafforgue, F Gatchitch… - … of the Royal …, 2015 - royalsocietypublishing.org
CRISPR-Cas is a form of adaptive sequence-specific immunity in microbes. This system
offers unique opportunities for the study of coevolution between bacteria and their viral …
offers unique opportunities for the study of coevolution between bacteria and their viral …
[HTML][HTML] Limiting damage during infection: lessons from infection tolerance for novel therapeutics
In the field of infectious disease control, novel therapies are focusing on reducing illness
caused by pathogens rather than on reducing the pathogen burden itself. Here, Vale and …
caused by pathogens rather than on reducing the pathogen burden itself. Here, Vale and …
Temperature‐dependent costs of parasitism and maintenance of polymorphism under genotype‐by‐environment interactions
The maintenance of genetic variation for infection‐related traits is often attributed to coevolution
between hosts and parasites, but it can also be maintained by environmental variation if …
between hosts and parasites, but it can also be maintained by environmental variation if …
Epidemiological, evolutionary, and coevolutionary implications of context-dependent parasitism
Victims of infection are expected to suffer increasingly as parasite population growth
increases. Yet, under some conditions, faster-growing parasites do not appear to cause more …
increases. Yet, under some conditions, faster-growing parasites do not appear to cause more …
Fecundity compensation and tolerance to a sterilizing pathogen in Daphnia
Hosts are armed with several lines of defence in the battle against parasites: they may prevent
the establishment of infection, reduce parasite growth once infected or persevere through …
the establishment of infection, reduce parasite growth once infected or persevere through …
[HTML][HTML] Measuring parasite fitness under genetic and thermal variation
Accurate measures of parasite fitness are essential to study host–parasite evolution. Parasite
fitness depends on several traits involved in establishing infection, growth and transmission…
fitness depends on several traits involved in establishing infection, growth and transmission…