User profiles for P. F. Vale

Pedro Vale

Institute of Ecology and Evolution, University of Edinburgh
Verified email at ed.ac.uk
Cited by 2058

Beyond killing: can we find new ways to manage infection?

PF Vale, L McNally, A Doeschl-Wilson… - … medicine, and public …, 2016 - academic.oup.com
The antibiotic pipeline is running dry and infectious disease remains a major threat to public
health. An efficient strategy to stay ahead of rapidly adapting pathogens should include …

CRISPR-mediated phage resistance and the ghost of coevolution past

PF Vale, TJ Little - Proceedings of the Royal Society B …, 2010 - royalsocietypublishing.org
The past is never dead. It's not even past William Faulkner (1951) Bacteria can acquire heritable
immunity to viral (phage) enemies by incorporating phage DNA into their own genome. …

[HTML][HTML] Co-infection alters population dynamics of infectious disease

H Susi, B Barrès, PF Vale, AL Laine - Nature communications, 2015 - nature.com
Co-infections by multiple pathogen strains are common in the wild. Theory predicts co-infections
to have major consequences for both within- and between-host disease dynamics, but …

How are arbovirus vectors able to tolerate infection?

JH Oliveira, AC Bahia, PF Vale - Developmental & Comparative …, 2020 - Elsevier
One of the defining features of mosquito vectors of arboviruses such as Dengue and Zika is
their ability to tolerate high levels of virus proliferation without suffering significant pathology. …

Costs of CRISPR-Cas-mediated resistance in Streptococcus thermophilus

PF Vale, G Lafforgue, F Gatchitch… - … of the Royal …, 2015 - royalsocietypublishing.org
CRISPR-Cas is a form of adaptive sequence-specific immunity in microbes. This system
offers unique opportunities for the study of coevolution between bacteria and their viral …

[HTML][HTML] Limiting damage during infection: lessons from infection tolerance for novel therapeutics

PF Vale, A Fenton, SP Brown - PLoS biology, 2014 - journals.plos.org
In the field of infectious disease control, novel therapies are focusing on reducing illness
caused by pathogens rather than on reducing the pathogen burden itself. Here, Vale and …

Temperature‐dependent costs of parasitism and maintenance of polymorphism under genotype‐by‐environment interactions

PF Vale, M Stjernman, TJ Little - Journal of evolutionary biology, 2008 - academic.oup.com
The maintenance of genetic variation for infection‐related traits is often attributed to coevolution
between hosts and parasites, but it can also be maintained by environmental variation if …

Epidemiological, evolutionary, and coevolutionary implications of context-dependent parasitism

PF Vale, AJ Wilson, A Best, M Boots… - The American …, 2011 - journals.uchicago.edu
Victims of infection are expected to suffer increasingly as parasite population growth
increases. Yet, under some conditions, faster-growing parasites do not appear to cause more …

Fecundity compensation and tolerance to a sterilizing pathogen in Daphnia

PF Vale, TJ Little - Journal of Evolutionary Biology, 2012 - academic.oup.com
Hosts are armed with several lines of defence in the battle against parasites: they may prevent
the establishment of infection, reduce parasite growth once infected or persevere through …

[HTML][HTML] Measuring parasite fitness under genetic and thermal variation

PF Vale, TJ Little - Heredity, 2009 - nature.com
Accurate measures of parasite fitness are essential to study host–parasite evolution. Parasite
fitness depends on several traits involved in establishing infection, growth and transmission…