Fitness landscapes have proven to be a valuable concept in evolutionary biology, combinatorial
optimization, and the physics of disordered systems. A fitness landscape is a mapping …

Significant fractions of eukaryotic genomes give rise to RNA, much of which is unannotated
and has reduced protein-coding potential. The genomic origins and the associations of …

Most functional RNA molecules have characteristic secondary structures that are highly
conserved in evolution. Here we present a method for computing the consensus structure of a …

Birds are the most species-rich class of tetrapod vertebrates and have wide relevance across
many research fields. We explored bird macroevolution using full genomes from 48 avian …

Genome sequencing of Helicobacter pylori has revealed the potential proteins and genetic
diversity of this prevalent human pathogen, yet little is known about its transcriptional …

One of the first specialized collections of nucleic acid sequences in life sciences was the ‘compilation
of tRNA sequences and sequences of tRNA genes’ ( http://www.trna.uni-bayreuth.…

We report an efficient method for detecting functional RNAs. The approach, which combines
comparative sequence analysis and structure prediction, already has yielded excellent …

Growing evidence shows that epigenetic mechanisms contribute to complex traits, with
implications across many fields of biology. In plant ecology, recent studies have attempted to …

Many years of extensive studies of metazoan mitochondrial genomes have established
differences in gene arrangements and genetic codes as valuable phylogenetic markers. …

Background Secondary structure forms an important intermediate level of description of nucleic
acids that encapsulates the dominating part of the folding energy, is often well conserved …