To identify potential therapeutic stop-gaps for SARS-CoV-2, we evaluated a library of 1,670
approved and reference compounds in an unbiased, cellular image-based screen for their …

ABSTRACT Development of accurate disease models and discovery of immune-modulating
drugs is challenged by the immune system’s highly interconnected and context-dependent …

… In ovarian follicle cells and imaginal discs, McLean and Cooley (p. 1445, published online
23 May) found that ring canals allowed diffusion of cytoplasmic proteins between cells and …

Ring canals connecting Drosophila germline, follicle and imaginal disc cells provide direct
contact of cytoplasm between cells. To date, little is known about the formation, structure, or …

Open-book examinations (OBEs) will likely become increasingly important assessment tools.
We investigated how access to open-book resources affected questions testing factual …

… 22 and BroadCitation 23 expression in stage 10a and 10b egg chambers, emphasizing the
cellular autonomy of the pathways responsible for dorsal appendage formation (McLean P, …

Assuming the ambient manifold is Kahler, the theory of complex submanifolds can be placed
in the more general context of calibrated submanifolds, see [HL]. It is therefore natural to try …

… Inhibition of ex vivo [ 3 H]PF-04767135 and [ 3 H]CI977 binding by PF-04455242 was …
PF-04455242 inhibited ex vivo binding to rat brain KOR receptors using [ 3 H]PF-04767135 (ID 50 …

By use of parallel chemistry coupled with physicochemical property design, a series of selective
κ opioid antagonists have been discovered. The parallel chemistry strategy utilized key …

In mammalian cells, transient gene expression (TGE) is a rapid, minimal-investment alternative
to single-copy integrations for testing of transgenic constructs. However, transient gene …