Longer human lives have led to a global burden of late-life disease. However, some older
people experience little ill health, a trait that should be extended to the general population. …

The classical twin study has been a powerful heuristic in biomedical, psychiatric and behavioural
research for decades. Twin registries worldwide have collected biological material and …

World-wide, research initiatives are in progress to establish the role of the epigenome in
human disease. Empirical data are still scarce, but particularly studies investigating how the …

… te Koppele, and PE Slagboom (unpublished data). Twin zygosity was determined by DNA
fingerprint analysis (Jeffreys et al. In the youngest group there were 16 MZ and 15 DZ pairs; …

Extensive epidemiologic studies have suggested that adult disease risk is associated with
adverse environmental conditions early in development. Although the mechanisms behind …

Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to
understand mechanisms underpinning gene regulation and disease. In the present study, we …

Prenatal famine in humans has been associated with various later-life consequences, depending
on the gestational timing of the insult and the sex of the exposed individual. Epigenetic …

Interindividual variation in mean leukocyte telomere length (LTL) is associated with cancer
and several age-associated diseases. We report here a genome-wide meta-analysis of …

Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at
risk of developing type 2 diabetes, cardiovascular disease and related metabolic and …

Retrotransposable elements are deleterious at many levels, and the failure of host
surveillance systems for these elements can thus have negative consequences. However, the …