Positive natural selection in the human lineage

PC Sabeti, SF Schaffner, B Fry, J Lohmueller, P Varilly… - science, 2006 - science.org
PCS is funded by the Damon Runyon Cancer Fellowship and the L'Oreal for Women in
Science Award. We … Sabeti, and four anonymous referees for careful review of our manuscript. …

[PDF][PDF] Structural and functional analysis of the D614G SARS-CoV-2 spike protein variant

…, JE Lemieux, JB Munro, A Rafique, A Barve, PC Sabeti… - Cell, 2020 - cell.com
The SARS-CoV-2 spike (S) protein variant D614G supplanted the ancestral virus worldwide,
reaching near fixation in a matter of months. Here we show that D614G was more infectious …

Genome-wide detection and characterization of positive selection in human populations

PC Sabeti, P Varilly, B Fry, J Lohmueller, E Hostetter… - Nature, 2007 - nature.com
With the advent of dense maps of human genetic variation, it is now possible to detect positive
natural selection across the human genome. Here we report an analysis of over 3 million …

Detecting recent positive selection in the human genome from haplotype structure

PC Sabeti, DE Reich, JM Higgins, HZP Levine… - Nature, 2002 - nature.com
The ability to detect recent natural selection in the human population would have profound
implications for the study of human history and for medicine. Here, we introduce a framework …

Detecting natural selection in genomic data

JJ Vitti, SR Grossman, PC Sabeti - Annual review of genetics, 2013 - annualreviews.org
The past fifty years have seen the development and application of numerous statistical
methods to identify genomic regions that appear to be shaped by natural selection. These …

Detecting novel associations in large data sets

…, ES Lander, M Mitzenmacher, PC Sabeti - science, 2011 - science.org
PCS and this work are supported by the Packard Foundation. For data set analysis, PCS
was also … PCS and this work are supported by the Packard Foundation. For data set analysis, …

[HTML][HTML] Natural selection and infectious disease in human populations

EK Karlsson, DP Kwiatkowski, PC Sabeti - Nature Reviews Genetics, 2014 - nature.com
The ancient biological 'arms race' between microbial pathogens and humans has shaped
genetic variation in modern populations, and this has important implications for the growing …

Linkage disequilibrium in the human genome

DE Reich, M Cargill, S Bolk, J Ireland, PC Sabeti… - Nature, 2001 - nature.com
With the availability of a dense genome-wide map of single nucleotide polymorphisms (SNPs)
1 , a central issue in human genetics is whether it is now possible to use linkage …

Nucleic acid detection with CRISPR-Cas13a/C2c2

…, J Livny, A Regev, EV Koonin, DT Hung, PC Sabeti… - Science, 2017 - science.org
… Benioff to PCS, and antibiotic resistance work was partially funded by J. and A. Bekenstein
… Benioff to PCS, and antibiotic resistance work was partially funded by J. and A. Bekenstein to …

[HTML][HTML] COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets

…, G Szabo, TL Tickle, PT Ellinor, D Hung, PC Sabeti… - Nature, 2021 - nature.com
COVID-19, which is caused by SARS-CoV-2, can result in acute respiratory distress syndrome
and multiple organ failure 1 , 2 , 3 – 4 , but little is known about its pathophysiology. Here …