User profiles for P. A. Khavari

Paul Khavari

Stanford University
Verified email at stanford.edu
Cited by 28694

Integrating single-cell and spatial transcriptomics to elucidate intercellular tissue dynamics

SK Longo, MG Guo, AL Ji, PA Khavari - Nature Reviews Genetics, 2021 - nature.com
Single-cell RNA sequencing (scRNA-seq) identifies cell subpopulations within tissue but
does not capture their spatial distribution nor reveal local networks of intercellular …

The functions and unique features of long intergenic non-coding RNA

JD Ransohoff, Y Wei, PA Khavari - Nature reviews Molecular cell …, 2018 - nature.com
Long intergenic non-coding RNA (lincRNA) genes have diverse features that distinguish
them from mRNA-encoding genes and exercise functions such as remodelling chromatin and …

Advances in skin grafting and treatment of cutaneous wounds

BK Sun, Z Siprashvili, PA Khavari - Science, 2014 - science.org
The ability of the skin to repair itself after injury is vital to human survival and is disrupted in
a spectrum of disorders. The process of cutaneous wound healing is complex, requiring a …

An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues

…, LA Orloff, VI Risca, A Kundaje, PA Khavari… - Nature …, 2017 - nature.com
We present Omni-ATAC, an improved ATAC-seq protocol for chromatin accessibility
profiling that works across multiple applications with substantial improvement of signal-to-…

Conjugation of arginine oligomers to cyclosporin A facilitates topical delivery and inhibition of inflammation

…, E Kreider, PL McGrane, PA Wender, PA Khavari - Nature medicine, 2000 - nature.com
Many systemically effective drugs such as cyclosporin A are ineffective topically because of
their poor penetration into skin. To surmount this problem, we conjugated a heptamer of …

[HTML][HTML] Multimodal analysis of composition and spatial architecture in human squamous cell carcinoma

…, SZ Aasi, GP Nolan, J Lundeberg, PA Khavari - Cell, 2020 - Elsevier
To define the cellular composition and architecture of cutaneous squamous cell carcinoma (cSCC),
we combined single-cell RNA sequencing with spatial transcriptomics and …

Purification and biochemical heterogeneity of the mammalian SWI‐SNF complex.

W Wang, J Côté, Y Xue, S Zhou, PA Khavari… - The EMBO …, 1996 - embopress.org
We have purified distinct complexes of nine to 12 proteins [referred to as BRG1‐associated
factors (BAFs)] from several mammalian cell lines using an antibody to the SWI2‐SNF2 …

Control of somatic tissue differentiation by the long non-coding RNA TINCR

…, S Aiyer, A Raj, JL Rinn, HY Chang, PA Khavari - Nature, 2013 - nature.com
Several of the thousands of human long non-coding RNAs (lncRNAs) have been
functionally characterized 1 , 2 , 3 , 4 ; however, potential roles for lncRNAs in somatic tissue …

Nucleosome disruption and enhancement of activator binding by a human SW1/SNF complex

H Kwon, AN Imbalzano, PA Khavari, RE Kingston… - Nature, 1994 - nature.com
CHROMATIN structure can affect the transcriptional activity of eukaryotic structural genes by
blocking access of sequence-specific activator proteins (activators) to their promoter-binding …

HiChIP: efficient and sensitive analysis of protein-directed genome architecture

MR Mumbach, AJ Rubin, RA Flynn, C Dai, PA Khavari… - Nature …, 2016 - nature.com
Genome conformation is central to gene control but challenging to interrogate. Here we
present HiChIP, a protein-centric chromatin conformation method. HiChIP improves the yield of …