… In a broad-ranging review, Michael Stratton, Peter Campbell and Andrew Futreal look back
at the achievements of cancer genomics, and forward to the prospect that the complete DNA …

A central aim of cancer research has been to identify the mutated genes that are causally
implicated in oncogenesis ('cancer genes'). After two decades of searching, how many have …

Recent advances in genome technologies and the ensuing outpouring of genomic information
related to cancer have accelerated the convergence of discovery science and clinical …

Preclinical mouse models suggest that the gut microbiome modulates tumor response to
checkpoint blockade immunotherapy; however, this has not been well-characterized in human …

Cancers arise owing to the accumulation of mutations in critical genes that alter normal
programmes of cell proliferation, differentiation and death. As the first stage of a systematic …

Background Intratumor heterogeneity may foster tumor evolution and adaptation and hinder
personalized-medicine strategies that depend on results from single tumor-biopsy samples. …

A strong candidate for the 17q-linked BRCA1 gene, which influences susceptibility to breast
and ovarian cancer, has been identified by positional cloning methods. Probable …

IN Western Europe and the United States approximately 1 in 12 women develop breast cancer.
A small proportion of breast cancer cases, in particular those arising at a young age, are …

Cancers arise owing to mutations in a subset of genes that confer growth advantage. The
availability of the human genome sequence led us to propose that systematic resequencing of …

Background The V617F mutation, which causes the substitution of phenylalanine for valine
at position 617 of the Janus kinase (JAK) 2 gene (JAK2), is often present in patients with …