Decoding how tissue properties emerge across multiple spatial and temporal scales from
the integration of local signals is a grand challenge in quantitative biology. For example, the …

The robust specification of organ development depends on coordinated cell-cell communication.
This process requires signal integration among multiple pathways, relying on second …

Mitotic rounding during cell division is critical for preventing daughter cells from inheriting an
abnormal number of chromosomes, a condition that occurs frequently in cancer cells. Cells …

Embryogenesis is an extraordinarily robust process, exhibiting the ability to control tissue
size and repair patterning defects in the face of environmental and genetic perturbations. The …

Mesenchymal stem cells (MSCs) derived from bone marrow are a powerful cellular resource
and have been used in numerous studies as potential candidates to develop strategies for …

Phenomics requires quantification of large volumes of image data, necessitating high
throughput image processing approaches. Existing image processing pipelines for Drosophila …

Wing disc pouches of fruit flies are a powerful genetic model for studying physiological
intercellular calcium (Ca 2+ ) signals for dynamic analysis of cell signaling in organ development …

In this study we describe the molecular and cellular characterization of a zebrafish mutant
that develops tumors in the optic pathway. Heterozygous Tg(flk1:RFP)is18 transgenic adults …

Recently, organ-scale intercellular Ca 2+ transients (ICTs) were reported in the Drosophila
wing disc. However, the functional in vivo significance of ICTs remains largely unknown. Here …

Fluorescence micrographs naturally exhibit darkening around their edges (vignetting), which
makes seamless stitching challenging. If vignetting is not corrected for, a stitched image will …