Advances using single-particle trajectories to reconstruct chromatin organization and dynamics

O Shukron, A Seeber, A Amitai, D Holcman - Trends in Genetics, 2019 - cell.com
Chromatin organization remains complex and far from understood. In this article, we review
recent statistical methods of extracting biophysical parameters from in vivo single-particle …

[HTML][HTML] Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD

S Basu, O Shukron, D Hall, P Parutto… - Nature structural & …, 2023 - nature.com
To understand how the nucleosome remodeling and deacetylase (NuRD) complex regulates
enhancers and enhancer–promoter interactions, we have developed an approach to …

Analyzing transformation of myelodysplastic syndrome to secondary acute myeloid leukemia using a large patient database

O Shukron, V Vainstein, A Kündgen… - American journal of …, 2012 - Wiley Online Library
One‐third of patients with myelodysplastic syndrome (MDS) progress to secondary acute
myeloid leukemia (sAML), with its concomitant poor prognosis. Recently, multiple mutations …

Statistics of randomly cross-linked polymer models to interpret chromatin conformation capture data

O Shukron, D Holcman - Physical Review E, 2017 - APS
Polymer models are used to describe chromatin, which can be folded at different spatial scales
by binding molecules. By folding, chromatin generates loops of various sizes. We present …

[HTML][HTML] Compulsive sexual behavior and sexual offending: Differences in cognitive schemas, sensation seeking, and impulsivity

Y Efrati, O Shukron, R Epstein - Journal of behavioral addictions, 2019 - akjournals.com
Background and aims People from the community seeking treatment in frameworks such as
Sexaholics Anonymous (SA) and sex offenders are preoccupied with sex, sexual fantasies, …

[HTML][HTML] Transient chromatin properties revealed by polymer models and stochastic simulations constructed from Chromosomal Capture data

O Shukron, D Holcman - PLoS computational biology, 2017 - journals.plos.org
Chromatin organization can be probed by Chromosomal Capture (5C) data, from which the
encounter probability (EP) between genomic sites is presented in a large matrix. This matrix …

Early maladaptive schemas are highly indicative of compulsive sexual behavior

Y Efrati, O Shukron, R Epstein - Evaluation & the Health …, 2021 - journals.sagepub.com
Unlike the consequences of compulsive sexual behavior (CSB) and the profile of people with
CSB that were extensively studied, the cognitive distortions that might be responsible to the …

Live-cell 3D single-molecule tracking reveals how NuRD modulates enhancer dynamics

S Basu, O Shukron, D Hall, P Parutto, A Ponjavic… - Biorxiv, 2020 - biorxiv.org
Enhancer-promoter dynamics are crucial for the spatiotemporal control of gene expression,
but it remains unclear whether these dynamics are controlled by chromatin regulators, such …

Cellular immunotherapy for high grade gliomas: mathematical analysis deriving efficacious infusion rates based on patient requirements

Y Kogan, U Foryś, O Shukron, N Kronik, Z Agur - SIAM Journal on Applied …, 2010 - SIAM
To date, no effective cure has been found for high grade malignant glioma (HGG), current
median survival for HGG patients under treatment ranging from 18 months (grade IV) to 5 …

Rapid rate of peripheral blood blast clearance accurately predicts complete remission in acute myeloid leukemia

V Vainstein, SA Buckley, O Shukron, EH Estey… - Leukemia, 2014 - nature.com
1 Rosenquist R, Cortese D, Bhoi S, Mansouri L, Gunnarsson R. Prognostic markers and their
clinical applicability in chronic lymphocytic leukemia: where do we stand? Leuk Lymphoma …