Advances using single-particle trajectories to reconstruct chromatin organization and dynamics
Chromatin organization remains complex and far from understood. In this article, we review
recent statistical methods of extracting biophysical parameters from in vivo single-particle …
recent statistical methods of extracting biophysical parameters from in vivo single-particle …
[HTML][HTML] Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD
To understand how the nucleosome remodeling and deacetylase (NuRD) complex regulates
enhancers and enhancer–promoter interactions, we have developed an approach to …
enhancers and enhancer–promoter interactions, we have developed an approach to …
Analyzing transformation of myelodysplastic syndrome to secondary acute myeloid leukemia using a large patient database
O Shukron, V Vainstein, A Kündgen… - American journal of …, 2012 - Wiley Online Library
One‐third of patients with myelodysplastic syndrome (MDS) progress to secondary acute
myeloid leukemia (sAML), with its concomitant poor prognosis. Recently, multiple mutations …
myeloid leukemia (sAML), with its concomitant poor prognosis. Recently, multiple mutations …
Statistics of randomly cross-linked polymer models to interpret chromatin conformation capture data
O Shukron, D Holcman - Physical Review E, 2017 - APS
Polymer models are used to describe chromatin, which can be folded at different spatial scales
by binding molecules. By folding, chromatin generates loops of various sizes. We present …
by binding molecules. By folding, chromatin generates loops of various sizes. We present …
[HTML][HTML] Compulsive sexual behavior and sexual offending: Differences in cognitive schemas, sensation seeking, and impulsivity
Y Efrati, O Shukron, R Epstein - Journal of behavioral addictions, 2019 - akjournals.com
Background and aims People from the community seeking treatment in frameworks such as
Sexaholics Anonymous (SA) and sex offenders are preoccupied with sex, sexual fantasies, …
Sexaholics Anonymous (SA) and sex offenders are preoccupied with sex, sexual fantasies, …
[HTML][HTML] Transient chromatin properties revealed by polymer models and stochastic simulations constructed from Chromosomal Capture data
O Shukron, D Holcman - PLoS computational biology, 2017 - journals.plos.org
Chromatin organization can be probed by Chromosomal Capture (5C) data, from which the
encounter probability (EP) between genomic sites is presented in a large matrix. This matrix …
encounter probability (EP) between genomic sites is presented in a large matrix. This matrix …
Early maladaptive schemas are highly indicative of compulsive sexual behavior
Y Efrati, O Shukron, R Epstein - Evaluation & the Health …, 2021 - journals.sagepub.com
Unlike the consequences of compulsive sexual behavior (CSB) and the profile of people with
CSB that were extensively studied, the cognitive distortions that might be responsible to the …
CSB that were extensively studied, the cognitive distortions that might be responsible to the …
Live-cell 3D single-molecule tracking reveals how NuRD modulates enhancer dynamics
Enhancer-promoter dynamics are crucial for the spatiotemporal control of gene expression,
but it remains unclear whether these dynamics are controlled by chromatin regulators, such …
but it remains unclear whether these dynamics are controlled by chromatin regulators, such …
Cellular immunotherapy for high grade gliomas: mathematical analysis deriving efficacious infusion rates based on patient requirements
Y Kogan, U Foryś, O Shukron, N Kronik, Z Agur - SIAM Journal on Applied …, 2010 - SIAM
To date, no effective cure has been found for high grade malignant glioma (HGG), current
median survival for HGG patients under treatment ranging from 18 months (grade IV) to 5 …
median survival for HGG patients under treatment ranging from 18 months (grade IV) to 5 …
Rapid rate of peripheral blood blast clearance accurately predicts complete remission in acute myeloid leukemia
V Vainstein, SA Buckley, O Shukron, EH Estey… - Leukemia, 2014 - nature.com
1 Rosenquist R, Cortese D, Bhoi S, Mansouri L, Gunnarsson R. Prognostic markers and their
clinical applicability in chronic lymphocytic leukemia: where do we stand? Leuk Lymphoma …
clinical applicability in chronic lymphocytic leukemia: where do we stand? Leuk Lymphoma …