… O) representing the mean green to red ratio for the entire metaphase is shown in a dashed
line and ratios 0.5 and 1.5 as dotted lines. Based on this analysis, the chromosomal regions …

Tissue microarray (TMA) technology allows rapid visualization of molecular targets in
thousands of tissue specimens at a time, either at the DNA, RNA or protein level. The technique …

CONTEXT: MicroRNAs (miRNA) are noncoding RNAs that post-transcriptionally regulate
gene expression. Their altered expression and function have been observed in most urologic …

Germline mutations in BRCA1 and BRCA2 confer high risks of breast and ovarian cancer,
but the average magnitude of these risks is uncertain and may depend on the context. …

… AK and O.-PK have received support from the Finnish Science Academy, Finnish and
Pirkanmaa Cancer Societies, Lahtikari Foundation, and Pirkanmaa Cultural Foundation (Finland). …

Members of the recently recognized SRC-1 family of transcriptional coactivators interact with
steroid hormone receptors to enhance ligand-dependent transcription. AIB1, a member of …

Background Many cases of hereditary breast cancer are due to mutations in either the
BRCA1 or the BRCA2 gene. The histopathological changes in these cancers are often …

Overexpression of amplified genes is often associated with the acquisition of resistance to
cancer therapeutic agents in vitro. We have identified a similar molecular mechanism in vivo …

To evaluate the timing of mutations in BRAF (v-raf murine sarcoma viral oncogene homolog
B1) during melanocytic neoplasia, we carried out mutation analysis on microdissected …

… lq (36% of primary tumors/40% of cell lines) and at 8q (27%/40%), whereas regional copy-number
increases were seen repeatedly at 17q22-q24 (18%/67%) and at 20q13 (18%/40%o). …