In some recent studies, a view emerged that stochastic dynamics governing the switching of
cells from one differentiation state to another could be characterized by a peak in gene …

… The work in O. Gandrillon's laboratory is supported by the Ligue contre le Cancer (Comité
départemental du Rhône), INSERM/AFM (joint program), the CNRS, the UCBL, the Fondation …

Motivation Single cell transcriptional profiling opens up a new avenue in studying the
functional role of cell-to-cell variability in physiological processes. The analysis of single cell …

In the present article, we will try to clarify what entropy is, how it is computed, and we will
show that the same quantity can be used to measure very different things. We will thus try to …

Background The recent development of single-cell transcriptomics has enabled gene
expression to be measured in individual cells instead of being population-averaged. Despite this …

… Beug and O.Gandrillon, unpublished). Pilot experiments suggest that T2ECs from chicken
blastoderms may retain the ability to produce embryonic-type globin chains throughout long …

Individual cells take lineage commitment decisions in a way that is not necessarily uniform.
We address this issue by characterising transcriptional changes in cord blood-derived CD34…

Background Inference of gene regulatory networks from gene expression data has been a
long-standing and notoriously difficult task in systems biology. Recently, single-cell …

… To analyze the effect of chromatin remodeling on promoter activation and therefore on
stochastic gene expression, Raser and O'Shea used yeast strains lacking components of the …

… In order to study the kinetics of erythrocyte populations, we performed a series of experiments
(in the Centre de Génétique Moléculaire et Cellulaire Laboratory, O. Gandrillon's team) to …