Biological properties of extracellular vesicles and their physiological functions

…, MHM Wauben, O De Wever - Journal of …, 2015 - Taylor & Francis
In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of
intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity …

Role of tissue stroma in cancer cell invasion

O De Wever, M Mareel - The Journal of Pathology: A Journal of …, 2003 - Wiley Online Library
… Myofibroblasts but not fibroblasts stimulate invasion of human colon cancer cells in 24–48
h invasion assays with collagen type I or Matrigel as a substrate (O De Wever, unpublished …

[HTML][HTML] Recent developments in myofibroblast biology: paradigms for connective tissue remodeling

…, A Desmoulière, J Varga, O De Wever… - The American journal of …, 2012 - Elsevier
The discovery of the myofibroblast has opened new perspectives for the comprehension of
the biological mechanisms involved in wound healing and fibrotic diseases. In recent years, …

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the …

…, EF De Santana, O De Wever… - Journal of …, 2018 - Wiley Online Library
The last decade has seen a sharp increase in the number of scientific publications describing
physiological and pathological functions of extracellular vesicles (EVs), a collective term …

EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research

…, M Wauben, KW Witwer, MI Zonneveld, O De Wever… - Nature …, 2017 - nature.com
We argue that the field of extracellular vesicle (EV) biology needs more transparent reporting
to facilitate interpretation and replication of experiments. To achieve this, we describe EV-…

The impact of disparate isolation methods for extracellular vesicles on downstream RNA profiling

…, J Vandesompele, M Bracke, O De Wever… - Journal of …, 2014 - Taylor & Francis
Despite an enormous interest in the role of extracellular vesicles, including exosomes, in
cancer and their use as biomarkers for diagnosis, prognosis, drug response and recurrence, …

Stromal myofibroblasts are drivers of invasive cancer growth

O De Wever, P Demetter, M Mareel… - International journal of …, 2008 - Wiley Online Library
… The proinvasive activity of human myofibroblasts in vitro was shown by De Wever et al.16
using human colon cancer cells and myofibroblasts isolated from surgical colon cancer …

Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization

…, N Vandamme, RE Vandenbroucke, O De Wever… - Nature …, 2021 - nature.com
Glioblastomas are aggressive primary brain cancers that recur as therapy-resistant tumors.
Myeloid cells control glioblastoma malignancy, but their dynamics during disease …

Methodological guidelines to study extracellular vesicles

…, S Sahoo, PRM Siljander, G Sturk, O De Wever… - Circulation …, 2017 - Am Heart Assoc
Owing to the relationship between extracellular vesicles (EVs) and physiological and pathological
conditions, the interest in EVs is exponentially growing. EVs hold high hopes for novel …

Tenascin‐C and SF/HGF produced by myofibroblasts in vitro provide convergent proinvasive signals to human colon cancer cells through RhoA and Rac

O De Wever, QD Nguyen, L Van Hoorde… - The FASEB …, 2004 - Wiley Online Library
De Bruyne are gratefully acknowledged for technical assistance and J. Roels for preparation
O. De Wever was supported by a fellowship from the Stichting Emmanuel van der Schueren…