An atlas of genetic associations in UK Biobank
O Canela-Xandri, K Rawlik, A Tenesa - Nature genetics, 2018 - nature.com
Genome-wide association studies (GWAS) have identified many loci contributing to variation
in complex traits, yet the majority of loci that contribute to the heritability of complex traits …
in complex traits, yet the majority of loci that contribute to the heritability of complex traits …
A multi-tissue atlas of regulatory variants in cattle
Abstract Characterization of genetic regulatory variants acting on livestock gene expression
is essential for interpreting the molecular mechanisms underlying traits of economic value …
is essential for interpreting the molecular mechanisms underlying traits of economic value …
Sex differences in genetic architecture in the UK Biobank
… unrelated (kinship coefficient <0.0442) individuals of white British descent, with missingness
rate >2% in the study cohort, paralleling the QC procedure followed by Canela-Xandri et al. …
rate >2% in the study cohort, paralleling the QC procedure followed by Canela-Xandri et al. …
[HTML][HTML] A compendium of genetic regulatory effects across pig tissues
…, D Crespo-Piazuelo, R Quintanilla, O Canela-Xandri… - Nature Genetics, 2024 - nature.com
The Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been established to
develop a public resource of genetic regulatory variants in livestock, which is essential for …
develop a public resource of genetic regulatory variants in livestock, which is essential for …
Comprehensive analyses of 723 transcriptomes enhance genetic and biological interpretations for complex traits in cattle
By uniformly analyzing 723 RNA-seq data from 91 tissues and cell types, we built a
comprehensive gene atlas and studied tissue specificity of genes in cattle. We demonstrated that …
comprehensive gene atlas and studied tissue specificity of genes in cattle. We demonstrated that …
Evaluating the contribution of genetics and familial shared environment to common disease using the UK Biobank
Genome-wide association studies have detected many loci underlying susceptibility to disease,
but most of the genetic factors that contribute to disease susceptibility remain unknown. …
but most of the genetic factors that contribute to disease susceptibility remain unknown. …
[HTML][HTML] Genome-wide study of hair colour in UK Biobank explains most of the SNP heritability
…, E Pairo-Castineira, K Rawlik, O Canela-Xandri… - Nature …, 2018 - nature.com
Natural hair colour within European populations is a complex genetic trait. Previous work has
established that MC1R variants are the principal genetic cause of red hair colour, but with …
established that MC1R variants are the principal genetic cause of red hair colour, but with …
[HTML][HTML] Evidence for sex-specific genetic architectures across a spectrum of human complex traits
K Rawlik, O Canela-Xandri, A Tenesa - Genome biology, 2016 - Springer
Background Sex differences are a common feature of human traits; however, the role sex
determination plays in human genetic variation remains unclear. The presence of gene-by-sex (…
determination plays in human genetic variation remains unclear. The presence of gene-by-sex (…
[HTML][HTML] Comparative transcriptome in large-scale human and cattle populations
Background Cross-species comparison of transcriptomes is important for elucidating evolutionary
molecular mechanisms underpinning phenotypic variation between and within species…
molecular mechanisms underpinning phenotypic variation between and within species…
[HTML][HTML] RNA-seq based detection of differentially expressed genes in the skeletal muscle of Duroc pigs with distinct lipid profiles
TF Cardoso, A Cánovas, O Canela-Xandri… - Scientific reports, 2017 - nature.com
We have used a RNA-seq approach to investigate differential expression in the skeletal
muscle of swine (N = 52) with divergent lipid profiles ie HIGH (increased intramuscular fat and …
muscle of swine (N = 52) with divergent lipid profiles ie HIGH (increased intramuscular fat and …