Calcium controls many critical events in the complex life cycles of apicomplexan parasites
including protein secretion, motility, and development. Calcium levels are normally tightly …

Publisher Summary This chapter discusses the complex factors regulating the infectivity of
the gametocyte to the mosquito vector and describes the patterns of parasite biology that …

Protein kinases (PKs) play crucial roles in the control of proliferation and differentiation in
eukaryotic cells. Research on protein phosphorylation has expanded tremendously in the past …

Malaria is transmitted from vertebrate host to mosquito vector by mature sexual blood-living
stages called gametocytes 1 , 2 . Within seconds of ingestion into the mosquito bloodmeal, …

Transmission of malaria parasites to mosquitoes is initiated by the obligatory sexual
reproduction of the parasite within the mosquito bloodmeal. Differentiation of specialized …

The genomes of malaria parasites contain many genes of unknown function. To assist drug
development through the identification of essential genes and pathways, we have measured …

Commitment to and completion of sexual development are essential for malaria parasites (protists
of the genus Plasmodium) to be transmitted through mosquitoes 1 . The molecular …

The cellular and molecular mechanisms that underlie species-specific membrane fusion
between male and female gametes remain largely unknown. Here, by use of gene discovery …

Background Rodent malaria parasites (RMP) are used extensively as models of human
malaria. Draft RMP genomes have been published for Plasmodium yoelii, P. berghei ANKA (PbA…

Malaria infection is initiated when Anopheles mosquitoes inject Plasmodium sporozoites
into the skin. Sporozoites subsequently reach the liver, invading and developing within …