In the loop: promoter–enhancer interactions and bioinformatics
Enhancer–promoter regulation is a fundamental mechanism underlying differential
transcriptional regulation. Spatial chromatin organization brings remote enhancers in contact with …
transcriptional regulation. Spatial chromatin organization brings remote enhancers in contact with …
RNA polymerase III (C) and its transcription factors
OS Gabrielsen - Trends in biochemical sciences, 1991 - Elsevier
Transcription of small genes by RNA polymerase III or C (pol III) involves many of the strategies
that are used for transcription complex formation and occasionally the same components …
that are used for transcription complex formation and occasionally the same components …
Specific DNA binding by c-Myb: evidence for a double helix-turn-helix-related motif
OS Gabrielsen, A Sentenac, P Fromageot - Science, 1991 - science.org
The c-Myb protein is a sequence-specific DNA binding protein that activates transcription in
hematopoietic cells. Three imperfect repeats (R 1 , R 2 , and R 3 ) that contain regularly …
hematopoietic cells. Three imperfect repeats (R 1 , R 2 , and R 3 ) that contain regularly …
DNA and redox state induced conformational changes in the DNA‐binding domain of the Myb oncoprotein.
…, N Jamin, PN Lirsac, F Toma, OS Gabrielsen - The EMBO …, 1993 - embopress.org
The DNA‐binding domain of the oncoprotein Myb comprises three imperfect repeats, R1,
R2 and R3. Only R2 and R3 are required for sequence‐specific DNA‐binding. Both are …
R2 and R3. Only R2 and R3 are required for sequence‐specific DNA‐binding. Both are …
FLASH acts as a co-activator of the transcription factor c-Myb and localizes to active RNA polymerase II foci
…, V Matre, S Gilfillan, Ø Dahle, OS Gabrielsen - Oncogene, 2008 - nature.com
The c-Myb oncoprotein is a DNA-binding transcription factor with a key role in early stages
of hematopoiesis. To expand our knowledge of partners cooperating with c-Myb, we …
of hematopoiesis. To expand our knowledge of partners cooperating with c-Myb, we …
CYP17 and Breast Cancer Risk: The Polymorphism in the 5′ Flanking Area of the Gene Does Not Influence Binding to Sp-1
…, PE Lønning, B Erikstein, R Kåresen, OS Gabrielsen… - Cancer research, 1999 - AACR
The ability of a motif of the CYP17 5′ untranslated region, created by a polymorphic T to C
substitution, to bind to the human transcription factor Sp-1 was investigated. No binding of …
substitution, to bind to the human transcription factor Sp-1 was investigated. No binding of …
Transactivation properties of c‐Myb are critically dependent on two SUMO‐1 acceptor sites that are conjugated in a PIASy enhanced manner
…, V Matre, G Del Sal, OS Gabrielsen - European journal of …, 2003 - Wiley Online Library
The transcription factor v‐Myb is a potent inducer of myeloid leukemias, and its cellular
homologue c‐Myb plays a crucial role in the regulation of hematopoiesis. Recently, Bies and …
homologue c‐Myb plays a crucial role in the regulation of hematopoiesis. Recently, Bies and …
Engineering of a Pichia pastoris expression system for secretion of high amounts of intact human parathyroid hormone
R Vad, E Nafstad, LA Dahl, OS Gabrielsen - Journal of biotechnology, 2005 - Elsevier
Human parathyroid hormone (hPTH) is involved in calcium metabolism, and the unique
ability of this hormone to stimulate bone growth makes it a promising agent in the treatment of …
ability of this hormone to stimulate bone growth makes it a promising agent in the treatment of …
Magnetic DNA affinity purification of yeast transcription factor τ—a new purification principle for the ultrarapid isolation of near homogeneous factor
OS Gabrielsen, E Horns, L Korsnes, A Ruet… - Nucleic acids …, 1989 - academic.oup.com
We present a new method for rapid purification to near homogeneity of sequence specific
DNA binding proteins based on magnetic separation. The method is described for the …
DNA binding proteins based on magnetic separation. The method is described for the …
A SUMO-regulated activation function controls synergy of c-Myb through a repressor–activator switch leading to differential p300 recruitment
…, H Kvaløy, V Matre, OS Gabrielsen - Nucleic acids …, 2010 - academic.oup.com
Synergy between transcription factors operating together on complex promoters is a key aspect
of gene activation. The ability of specific factors to synergize is restricted by sumoylation (…
of gene activation. The ability of specific factors to synergize is restricted by sumoylation (…