In the loop: promoter–enhancer interactions and bioinformatics

A Mora, GK Sandve, OS Gabrielsen… - Briefings in …, 2016 - academic.oup.com
Enhancer–promoter regulation is a fundamental mechanism underlying differential
transcriptional regulation. Spatial chromatin organization brings remote enhancers in contact with …

RNA polymerase III (C) and its transcription factors

OS Gabrielsen - Trends in biochemical sciences, 1991 - Elsevier
Transcription of small genes by RNA polymerase III or C (pol III) involves many of the strategies
that are used for transcription complex formation and occasionally the same components …

Specific DNA binding by c-Myb: evidence for a double helix-turn-helix-related motif

OS Gabrielsen, A Sentenac, P Fromageot - Science, 1991 - science.org
The c-Myb protein is a sequence-specific DNA binding protein that activates transcription in
hematopoietic cells. Three imperfect repeats (R 1 , R 2 , and R 3 ) that contain regularly …

DNA and redox state induced conformational changes in the DNA‐binding domain of the Myb oncoprotein.

…, N Jamin, PN Lirsac, F Toma, OS Gabrielsen - The EMBO …, 1993 - embopress.org
The DNA‐binding domain of the oncoprotein Myb comprises three imperfect repeats, R1,
R2 and R3. Only R2 and R3 are required for sequence‐specific DNA‐binding. Both are …

FLASH acts as a co-activator of the transcription factor c-Myb and localizes to active RNA polymerase II foci

…, V Matre, S Gilfillan, Ø Dahle, OS Gabrielsen - Oncogene, 2008 - nature.com
The c-Myb oncoprotein is a DNA-binding transcription factor with a key role in early stages
of hematopoiesis. To expand our knowledge of partners cooperating with c-Myb, we …

CYP17 and Breast Cancer Risk: The Polymorphism in the 5′ Flanking Area of the Gene Does Not Influence Binding to Sp-1

…, PE Lønning, B Erikstein, R Kåresen, OS Gabrielsen… - Cancer research, 1999 - AACR
The ability of a motif of the CYP17 5′ untranslated region, created by a polymorphic T to C
substitution, to bind to the human transcription factor Sp-1 was investigated. No binding of …

Transactivation properties of c‐Myb are critically dependent on two SUMO‐1 acceptor sites that are conjugated in a PIASy enhanced manner

…, V Matre, G Del Sal, OS Gabrielsen - European journal of …, 2003 - Wiley Online Library
The transcription factor v‐Myb is a potent inducer of myeloid leukemias, and its cellular
homologue c‐Myb plays a crucial role in the regulation of hematopoiesis. Recently, Bies and …

Engineering of a Pichia pastoris expression system for secretion of high amounts of intact human parathyroid hormone

R Vad, E Nafstad, LA Dahl, OS Gabrielsen - Journal of biotechnology, 2005 - Elsevier
Human parathyroid hormone (hPTH) is involved in calcium metabolism, and the unique
ability of this hormone to stimulate bone growth makes it a promising agent in the treatment of …

Magnetic DNA affinity purification of yeast transcription factor τ—a new purification principle for the ultrarapid isolation of near homogeneous factor

OS Gabrielsen, E Horns, L Korsnes, A Ruet… - Nucleic acids …, 1989 - academic.oup.com
We present a new method for rapid purification to near homogeneity of sequence specific
DNA binding proteins based on magnetic separation. The method is described for the …

A SUMO-regulated activation function controls synergy of c-Myb through a repressor–activator switch leading to differential p300 recruitment

…, H Kvaløy, V Matre, OS Gabrielsen - Nucleic acids …, 2010 - academic.oup.com
Synergy between transcription factors operating together on complex promoters is a key aspect
of gene activation. The ability of specific factors to synergize is restricted by sumoylation (…