The consequences of injuries to the CNS are profound and persistent, resulting in substantial
burden to both the individual patient and society. Existing treatments for CNS injuries such …

The bone morphogenetic proteins (BMPs) are a group of powerful morphogens that are critical
for development of the nervous system. The effects of BMP signaling on neural stem cells …

Aims Genetics plays an important role in coronary heart disease (CHD) but the clinical utility
of genomic risk scores (GRSs) relative to clinical risk scores, such as the Framingham Risk …

… luciferase assays, the Northwestern University Transgenic and Targeted Mutagenesis Core
for their assistance with generating ROSA-miR21 and ROSA-MSP mice, and Deeti Bhalala …

Practical application of genomic-based risk stratification to clinical diagnosis is appealing
yet performance varies widely depending on the disease and genomic risk score (GRS) …

Schizophrenia and the affective disorders, here comprising bipolar disorder and major
depressive disorder, are psychiatric illnesses that lead to significant morbidity and mortality …

Coronary artery disease (CAD) is a complex disease driven by myriad interactions of genetics
and environmental factors. Traditionally, studies have analyzed only 1 disease factor at a …

Neurotrauma results in significant morbidity and mortality, due in large part to the vast array
of cellular changes occurring in the central nervous system (CNS). Elucidating the complex …

Late-onset Alzheimer’s disease is the leading cause of dementia worldwide, accounting for
a growing burden of morbidity and mortality. Diagnosing Alzheimer’s disease before …

Spinal cord injury (SCI) is a debilitating injury with significant morbidity and mortalitiy.
Understanding the pathogensis of and developing treatments for SCI requires robust animal …