CRISPR-Cas adaptive immune systems defend microbes against foreign nucleic acids via
RNA-guided endonucleases. Using a computational sequence database mining approach, …

… OA … OA and JG analyzed PAM detection data. DS contributed to computational analysis of
… Gootenberg JS, Abudayyeh OO, Kellner MJ, Joung J, Collins JJ, Zhang F: Multiplexed and …

CRISPR-Cas (clustered regularly interspaced short palindromic repeats and CRISPR-associated
proteins) systems are divided into two classes, Class 1 systems, which utilize multiple …

Rapid, inexpensive, and sensitive nucleic acid detection may aid point-of-care pathogen
detection, genotyping, and disease monitoring. The RNA-guided, RNA-targeting clustered …

Rapid detection of nucleic acids is integral for clinical diagnostics and biotechnological
applications. We recently developed a platform termed SHERLOCK (specific high-sensitivity …

Background Most youth and young adult (YA) tobacco users use flavoured products; however,
little is known about specific flavours used. Methods We report flavour types among US …

… is a case of a 34-year-old patient with SH2B1 heterozygous variant in the LMP and multiple
obesity comorbidities including GERD, obstructive sleep apnea (OSA), and osteoarthritis …

… The most common comorbidities in this population were hypertension, diabetes, and
osteoarthritis. Wound infection occurred in 4 (9.8%) patients; 88% of the patients received a …

Background and aims Randomized clinical trials have proven the efficacy and safety of Food
and Drug Administration (FDA) approved anti-obesity medications (AOMs) for long-term use…

Nucleic acid editing holds promise for treating genetic disease, particularly at the RNA level,
where disease-relevant sequences can be rescued to yield functional protein products. …