… , were included in the model as NONSTERILE (n = 1,509). Genes annotated with a sterile …
(n = 536). The remaining genes were left as UNKNOWN and not included in modeling (n = …

Scientists are rapidly developing synthetic gene drive elements intended for release into
natural populations. These are intended to control or eradicate disease vectors and pests, or to …

… are converted into D N alleles with probability hn and into D alleles with probability h(1 –
n), where n is the probability that new products of homing retain the NotI site, and 1 – n is the …

It has been theorized that inducing extreme reproductive sex ratios could be a method to
suppress or eliminate pest populations. Limited knowledge about the genetic makeup and …

In the last 10 years the availability of the genome sequence of Anopheles gambiae and the
development of a transgenic technology for several species of Anopheles mosquitoes have, …

We have exploited the high selectivity of the homing endonuclease I-PpoI for the X-linked
Anopheles gambiae 28S ribosomal genes to selectively target X chromosome carrying …

… Residual somatic expression of the CRISPR SD transgene may explain reduced fertility in
strain N, … Windbichler, N. et al. Homing endonuclease mediated gene targeting in Anopheles …

… The plasmid pP[v+,70I-SceI] ( 30 ) expresses the I-SceI ORF with an N-terminal SV40
NLS and hemagglutinin (HA) tag under the control of the Drosophila Hsp70 promoter, which …

Y chromosomes control essential male functions in many species, including sex determination
and fertility. However, because of obstacles posed by repeat-rich heterochromatin, …

… The most conserved portion is located in the N-terminal region, where a consensus
hexapeptide KXNSRT occurs (fig. S9). We confirmed by PCR of male and female genomic DNA (…