User profiles for N. Weisenfeld

Neil I. Weisenfeld

Staff Scientist, 10x Genomics, Inc.
Verified email at 10xgenomics.com
Cited by 6307

Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: evidence from a novel positron emission tomography method

…, DR Weinberger, N Weisenfeld… - Proceedings of the …, 1997 - National Acad Sciences
A major line of evidence that supports the hypothesis of dopamine overactivity in schizophrenia
is the psychomimetic potential of agents such as amphetamine that stimulate dopamine …

A single-cell and spatially resolved atlas of human breast cancers

…, T Wang, L Larsson, D Kaczorowski, NI Weisenfeld… - Nature …, 2021 - nature.com
Breast cancers are complex cellular ecosystems where heterotypic interactions play central
roles in disease progression and response to therapy. However, our knowledge of their …

Direct determination of diploid genome sequences

NI Weisenfeld, V Kumar, P Shah, DM Church… - Genome …, 2017 - genome.cshlp.org
… Assemblies have been deposited at DDBJ/ENA/GenBank (https://www.ncbi.nlm.gov/genbank/)
under the accessions MSBx000 00000 where x is in {J,K,L,M,N,O,P}, and the versions …

Association of ketamine-induced psychosis with focal activation of the prefrontal cortex in healthy volunteers.

…, AK Malhotra, DA Pinals, NI Weisenfeld… - The American journal …, 1997 - europepmc.org
Objective Agents that antagonize the N-methyl-D-aspartic acid (NMDA) receptor, such as
phencyclidine and ketamine, produce an acute psychotic state in normal individuals that …

[HTML][HTML] NIDCAP improves brain function and structure in preterm infants with severe intrauterine growth restriction

…, SC Butler, L Lightbody, S Kosta, NI Weisenfeld… - Journal of …, 2012 - nature.com
… processes underlying NIDCAP effectiveness are speculative, which is a serious limitation
of the study: NIDCAP may reduce iatrogenic NICU damage by resetting the NMDA (N-methyl-D…

[HTML][HTML] A spatially resolved brain region-and cell type-specific isoform atlas of the postnatal mouse brain

…, B Haase, A Hayes, JG Chew, NI Weisenfeld… - Nature …, 2021 - nature.com
Splicing varies across brain regions, but the single-cell resolution of regional variation is
unclear. We present a single-cell investigation of differential isoform expression (DIE) between …

[PDF][PDF] Dissecting the causal mechanism of X-linked dystonia-parkinsonism by integrating genome and transcriptome assembly

…, D Henderson, N Ito, N Weisenfeld, D Jaffe, N Sharma… - Cell, 2018 - cell.com
… the probands for whom the age of disease onset could be determined (n = 303). A subset
of these probands (n = 263) were able to provide further clinical information about the pattern …

Comprehensive variation discovery in single human genomes

NI Weisenfeld, S Yin, T Sharpe, B Lau, R Hegarty… - Nature …, 2014 - nature.com
Complete knowledge of the genetic variation in individual human genomes is a crucial
foundation for understanding the etiology of disease. Genetic variation is typically characterized …

Automatic segmentation of newborn brain MRI

NI Weisenfeld, SK Warfield - Neuroimage, 2009 - Elsevier
Quantitative brain tissue segmentation from newborn MRI offers the possibility of improved
clinical decision making and diagnosis, new insight into the mechanisms of disease, and new …

Capturing intraoperative deformations: research experience at Brigham and Women's Hospital

…, SJ Haker, IF Talos, CA Kemper, N Weisenfeld… - Medical image …, 2005 - Elsevier
… Hence the interpolating function of node i of tetrahedral element e is defined as N i e ( x ) = 1
6 … We define the matrix B i e = L N i e at each node of each element, and since the energy of …