… These early compounds bound in the ATP-binding pocket residing in the cleft between
the N- and C-lobes of kinases. Even today, the majority of kinase inhibitors bind via a similar …

… Mean true positive rate and standard deviation (n = 5) are shown when models are built …
between cell lines derived from haematopoietic (n = 61) and solid tumours (n = 387). The middle …

Despite recent insights into melanoma genetics, systematic surveys for driver mutations are
challenged by an abundance of passenger mutations caused by carcinogenic UV light …

Liver cancer has the second highest worldwide cancer mortality rate and has limited
therapeutic options. We analyzed 363 hepatocellular carcinoma (HCC) cases by whole-exome …

Major international projects are underway that are aimed at creating a comprehensive catalogue
of all the genes responsible for the initiation and progression of cancer 1 , 2 , 3 , 4 , 5 , 6 …

Prostate cancer is the second most common cancer in men worldwide and causes over
250,000 deaths each year 1 . Overtreatment of indolent disease also results in significant …

… pre-injection cells compared to tumours, for n = 5 tumours for the transporter pool and n =
12 tumours for the metabolic enzyme pool, or to cells at day 25–28 for n = 4 in vitro cultures. P …

Head and neck squamous cell carcinoma (HNSCC) is a common, morbid, and frequently
lethal malignancy. To uncover its mutational spectrum, we analyzed whole-exome sequencing …

Breast carcinoma is the leading cause of cancer-related mortality in women worldwide, with
an estimated 1.38 million new cases and 458,000 deaths in 2008 alone 1 . This malignancy …

… r = n i /(n i + n s ). We required each exon ratio to be supported by at least 10 reads (n i + n s
… We used log(50 + N), in which N is the nSolver normalized value to reduce the effect of the …