Activation of T cells by antigen-presenting cells (APCs) depends on the complex integration
of signals that are delivered by multiple antigen receptors. Most receptor-proximal activation …

Microtubule disruption has dramatic effects on the normal centrosomal localization of the
Golgi complex, with Golgi elements remaining as competent functional units but undergoing a …

The mechanism by which Golgi membrane proteins are retained within the Golgi complex in
the midst of a continuous flow of protein and lipid is not yet understood. The diffusional …

The Golgi complex is a dynamic organelle engaged in both secretory and retrograde
membrane traffic. Here, we use green fluorescent protein–Golgi protein chimeras to study Golgi …

… We excluded a few GPCRs with extremely long N termini and a few that could not be
expressed in Escherichia coli, generating a total of 315 synthetic Tango-ized GPCRs (…

… Brain sections between Bregma −1.22 mm and −2.06 mm were chosen for analysis (n =
5 sections per mouse for hippocampus and n = 3–5 sections per mouse for striatum). …

Therapeutics that target ERBB2, such as lapatinib, often provide initial clinical benefit, but
resistance frequently develops. Adaptive responses leading to lapatinib resistance involve …

Cerebral cavernous malformations (CCM) are vascular lesions causing seizures and stroke.
Mutations causing inactivation of one of three genes, ccm1, -2, or -3, are sufficient to induce …

Targeting the dysregulated BRAF–MEK–ERK pathway in cancer has increasingly emerged
in clinical trial design. Despite clinical responses in specific cancers using inhibitors …

Here, we describe a newly generated transgenic mouse in which the Gs DREADD (rM3Ds),
an engineered G protein-coupled receptor, is selectively expressed in striatopallidal medium …