The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated
with various adult diseases. Using 1000 Genomes Project–imputed genotype data in up to …

The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated
with various adult diseases. Here, we analyse 1000-Genome reference panel imputed …

… neither thelarche nor menarche data available; n = 4), one or both parents originated from
a non-European country (n = 96), missing BMI data (n = 2), or no DNA available (n = 243). The …

… We successfully assigned 40.8% (n = 1790 in cis, n = 423 in trans) of the 5442 genetic
variants as protein-specific and 5.9% (n = 236 in cis, n = 86 in trans) as pathway-specific on the …

Background Delta-like homolog 1 (DLK1), also called preadipocyte factor 1, prevents
adipocyte differentiation and has been considered a molecular gatekeeper of adipogenesis. A …

Maternal obesity is increasingly prevalent and may affect the long-term health of the child.
We investigated the effects of maternal diet-induced obesity in mice on offspring metabolic …

MKRN3 mutations represent the most common genetic cause of central precocious puberty (CPP)
but associations between genotype and clinical features have not been extensively …

… based on our methodology and clinical Tanner staging occurred during transition periods
from prepubertal to pubertal status (n = 6) or pubertal to postpubertal status (n = 15). …

Background A large multicentre European study reported later onset of menopause among
women residing in greener areas. This influence on the timing of a reproductive event like …

Context Variation in pubertal timing is associated with a wide range of adult risks and
outcomes, but it is unclear whether these associations are causal, and it is largely unknown …