Recent research on disparate psychiatric disorders has implicated rare variants in genes
involved in global gene regulation and chromatin modification, as well as many common …

Genetic and genomic approaches have implicated hundreds of genetic loci in neurodevelopmental
disorders and neurodegeneration, but mechanistic understanding continues to lag …

Hundreds of genetic loci increasing risk for neuropsychiatric disorders have recently been
identified. This success, perhaps paradoxically, has posed challenges for therapeutic …

Multiple studies have confirmed the contribution of rare de novo copy number variations to
the risk for autism spectrum disorders 1 , 2 , 3 . But whereas de novo single nucleotide …

Genetic studies have identified dozens of autism spectrum disorder (ASD) susceptibility
genes, raising two critical questions: (1) do these genetic loci converge on specific biological …

The predisposition to neuropsychiatric disease involves a complex, polygenic, and pleiotropic
genetic architecture. However, little is known about how genetic variants impart brain …

Obesity is associated with increased risk for cardiovascular health problems including
diabetes, hypertension, and stroke. These cardiovascular afflictions increase risk for cognitive …

Autism spectrum disorder (ASD) involves substantial genetic contributions. These contributions
are profoundly heterogeneous but may converge on common pathways that are not yet …

Alternative splicing (AS) generates vast transcriptomic and proteomic complexity. However,
which of the myriad of detected AS events provide important biological functions is not well …

Three-dimensional physical interactions within chromosomes dynamically regulate gene
expression in a tissue-specific manner 1 , 2 , 3 . However, the 3D organization of chromosomes …