Cellular senescence is a well-established driver of aging and age-related diseases. There
are many challenges to mapping senescent cells in tissues such as the absence of specific …

Cellular senescence, an irreversible growth arrest triggered by a variety of stressors, plays
important roles in normal physiology and tumor suppression, but accumulation of senescent …

Retrotransposable elements are deleterious at many levels, and the failure of host
surveillance systems for these elements can thus have negative consequences. However, the …

Replicative cellular senescence is an important tumor suppression mechanism and also
contributes to aging. Progression of both cancer and aging include significant epigenetic …

… All data are mean ± SEM with n = 9–11 for old mice, n = 7–8 for young mice. *p < 0.05, **p <
0.01 … All data are mean ± SEM with n = 5–9 for AE ad n = 6–10 for FK. *p < 0.05, **p < 0.01 …

Mice deficient for SIRT6 exhibit a severely shortened lifespan, growth retardation, and
highly elevated LINE1 (L1) activity. Here we report that SIRT6-deficient cells and tissues …

Transposable elements (TEs) were discovered by Barbara McClintock in maize and have
since been found to be ubiquitous in all living organisms. Transposition is mutagenic and …

Background The c-Myc transcription factor is a master regulator and integrates cell
proliferation, cell growth and metabolism through activating thousands of target genes. Our …

… Third, we can count reads that map to a single repetitive element subfamily assembly once
and assign reads that map to multiple subfamilies using a fractional value 1/N s (where N s is …

MYC is a highly pleiotropic transcription factor whose deregulation promotes cancer. In contrast,
we find that Myc haploinsufficient (Myc +/– ) mice exhibit increased lifespan. They show …