Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy
IgA nephropathy (IgAN) is a progressive form of kidney disease defined by glomerular
deposition of IgA. Here we performed a genome-wide association study of 10,146 kidney-biopsy-…
deposition of IgA. Here we performed a genome-wide association study of 10,146 kidney-biopsy-…
[HTML][HTML] The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis
J Xie, L Liu, N Mladkova, Y Li, H Ren, W Wang… - Nature …, 2020 - nature.com
Membranous Nephropathy (MN) is a rare autoimmune cause of kidney failure. Here we
report a genome-wide association study (GWAS) for primary MN in 3,782 cases and 9,038 …
report a genome-wide association study (GWAS) for primary MN in 3,782 cases and 9,038 …
[HTML][HTML] GWAS for serum galactose-deficient IgA1 implicates critical genes of the O-glycosylation pathway
…, H Suzuki, C Reily, P Hou, J Xie, N Mladkova… - PLoS …, 2017 - journals.plos.org
… Subsequently, we analyzed all cohorts (N = 2,633) jointly to identify genome-wide significant
loci (Table 2, S2 Table). Our power calculations demonstrate that our design provides …
loci (Table 2, S2 Table). Our power calculations demonstrate that our design provides …
[HTML][HTML] Key differences identified between actinic keratosis and cutaneous squamous cell carcinoma by transcriptome profiling
SR Lambert, N Mladkova, A Gulati, R Hamoudi… - British journal of …, 2014 - nature.com
Background: Cutaneous squamous cell carcinoma (cSCC) is one of the most common
malignancies in fair-skinned populations worldwide and its incidence is increasing. Despite …
malignancies in fair-skinned populations worldwide and its incidence is increasing. Despite …
[HTML][HTML] NT5E (CD73) is epigenetically regulated in malignant melanoma and associated with metastatic site specificity
…, M Monteverde, R Matin, K Purdie, N Mladkova… - British Journal of …, 2012 - nature.com
Background: Novel prognostic biomarkers and therapeutic strategies are urgently required
for malignant melanoma. Ecto-5-prime-nucleotidase (NT5E; CD73) overexpression has been …
for malignant melanoma. Ecto-5-prime-nucleotidase (NT5E; CD73) overexpression has been …
The genomics and epigenetics of olfactory neuroblastoma: A systematic review
…, E Izumchenko, DM Blakaj, N Mladkova… - Laryngoscope …, 2021 - Wiley Online Library
Background Olfactory neuroblastoma (ONB) or esthesioneuroblastoma (ENB) is a rare
malignancy of the nasal cavity believed to arise from the olfactory epithelium. The goal of this …
malignancy of the nasal cavity believed to arise from the olfactory epithelium. The goal of this …
Fine mapping implicates a deletion of CFHR1 and CFHR3 in protection from IgA nephropathy in Han Chinese
J Xie, K Kiryluk, Y Li, N Mladkova, L Zhu… - Journal of the …, 2016 - journals.lww.com
… Recent data indicate that CFHR1, CFHR2, and CFHR5 can form heterodimers via their N-terminal
domains and essentially act as CFH antagonists by competing with CFH for C3b …
domains and essentially act as CFH antagonists by competing with CFH for C3b …
Prevalence of depression and depressive symptoms in patients with systemic lupus erythematosus: Iranian experience
Z Zakeri, M Shakiba, B Narouie, N Mladkova… - Rheumatology …, 2012 - Springer
Psychiatric disorders including depression represent clinical manifestation of systemic lupus
erythematosus (SLE). Recognition of depression in SLE patients is of utmost importance …
erythematosus (SLE). Recognition of depression in SLE patients is of utmost importance …
miR-4516 predicts poor prognosis and functions as a novel oncogene via targeting PTPN14 in human glioblastoma
…, AP Becker, PM Gulati, M Geurts, N Mladkova… - Oncogene, 2019 - nature.com
… GBM patients with high (n = 134) and low (n = 134) expression of miR-4516. b qRT-PCR
analysis of miR-4516 expression in grade II (n = 8), grade III (n = 8), and grade IV (n = 8) glioma …
analysis of miR-4516 expression in grade II (n = 8), grade III (n = 8), and grade IV (n = 8) glioma …
Diagnostic value of sonohysterography in the determination of fallopian tube patency as an initial step of routine infertility assessment
…, M Ghasemi-Rad, Z Yekta, N Mladkova - … of Ultrasound in …, 2009 - Wiley Online Library
Objectives. Infertility is defined as the failure to conceive after 1 year of regular unprotected
intercourse. It affects 10% to 15% of couples. Sonohysterography (SHG) is an accurate …
intercourse. It affects 10% to 15% of couples. Sonohysterography (SHG) is an accurate …