Epithelial-to-mesenchymal and endothelial-to-mesenchymal transition: from cardiovascular development to disease

JC Kovacic, N Mercader, M Torres, M Boehm… - Circulation, 2012 - Am Heart Assoc
Cellular switching from an epithelial-to-mesenchymal phenotype, and conversely from a
mesenchymal-toepithelial phenotype, are important biological programs that are operative from …

[HTML][HTML] COVID-19 and the vasculature: current aspects and long-term consequences

…, C Stüdle, I Piragyte, N Mercader… - Frontiers in cell and …, 2022 - frontiersin.org
… The N protein further induces a strong immune response fostering the production of specific
antibodies (IgA, IgG, and IgM) which are also useful for diagnostic testing of COVID-19 (…

Model systems for regeneration: zebrafish

IJ Marques, E Lupi, N Mercader - Development, 2019 - journals.biologists.com
Tissue damage can resolve completely through healing and regeneration, or can produce
permanent scarring and loss of function. The response to tissue damage varies across tissues …

Extensive scar formation and regression during heart regeneration after cryoinjury in zebrafish

…, V Martín, M Peralta, M Torres, N Mercader - …, 2011 - journals.biologists.com
… 1D,D′) (n=6). At 130 dpi the scar had almost completely disappeared (n=4) (Fig. 1E,E′). …
5L-N). Expression was particularly intense at the border of the IA and in a subset of epicardial …

Conserved regulation of proximodistal limb axis development by Meis1/Hth

N Mercader, E Leonardo, N Azpiazu, A Serrano… - Nature, 1999 - nature.com
… 30–35 infected limbs showed that size reduction always involved the zeugopod and autopod
(n = 57/75). Only very rarely (n = 4) was the stylopod slightly reduced (Fig. 2a–d). Given …

Opposing RA and FGF signals control proximodistal vertebrate limb development through regulation of Meis genes

N Mercader, E Leonardo, ME Piedra… - …, 2000 - journals.biologists.com
Vertebrate limbs develop in a temporal proximodistal sequence, with proximal regions specified
and generated earlier than distal ones. Whereas considerable information is available …

Mechanism of super-assembly of respiratory complexes III and IV

…, C Garcia-Poyatos, I Ezkurdia, N Mercader… - Nature, 2016 - nature.com
Respiratory chain complexes can super-assemble into quaternary structures called
supercomplexes that optimize cellular metabolism 1 . The interaction between complexes III (CIII) …

Transient fibrosis resolves via fibroblast inactivation in the regenerating zebrafish heart

…, J Sainz de Aja, X Langa, N Mercader - Proceedings of the …, 2018 - National Acad Sciences
In the zebrafish (Danio rerio), regeneration and fibrosis after cardiac injury are not mutually
exclusive responses. Upon cardiac cryoinjury, collagen and other extracellular matrix (ECM) …

[HTML][HTML] Pan-epicardial lineage tracing reveals that epicardium derived cells give rise to myofibroblasts and perivascular cells during zebrafish heart regeneration

JM González-Rosa, M Peralta, N Mercader - Developmental biology, 2012 - Elsevier
Myocardial infarction (MI) leads to a severe loss of cardiomyocytes, which in mammals are
replaced by scar tissue. Epicardial derived cells (EPDCs) have been reported to differentiate …

Proximodistal identity during vertebrate limb regeneration is regulated by Meis homeodomain proteins

N Mercader, EM Tanaka, M Torres - 2005 - journals.biologists.com
… (Capdevila et al.,1999), leads to a proximal shift of limb identities along the PD axis (Mercader
et al., 1999),and proximalizes distal limb cell affinity properties(Mercader et al., 2000). …