[HTML][HTML] microRNAs and genetic diseases

N Meola, VA Gennarino, S Banfi - Pathogenetics, 2009 - Springer
microRNAs (miRNAs) are a class of small RNAs (19-25 nucleotides in length) processed from
double-stranded hairpin precursors. They negatively regulate gene expression in animals, …

[PDF][PDF] Identification of a nuclear exosome decay pathway for processed transcripts

N Meola, M Domanski, E Karadoulama, Y Chen… - Molecular cell, 2016 - cell.com
… For statistical analysis, all data are displayed as mean values with error bars denoting
SDs (n = 3 biological replicates). In (C) and (D), asterisks indicate detection of proteins of …

MicroRNA target prediction by expression analysis of host genes

…, M Sardiello, R Avellino, N Meola… - Genome …, 2009 - genome.cshlp.org
… These genes had previously been validated as targets of 20 different intragenic miRNAs
either at the mRNA (n = 34) or at the translational (n = 22) level (Supplemental Table S1). We …

The long noncoding RNA Vax2os1 controls the cell cycle progression of photoreceptor progenitors in the mouse retina

N Meola, M Pizzo, G Alfano, EM Surace, S Banfi - Rna, 2012 - rnajournal.cshlp.org
… (J–L) Values are means ± SEM (n = 4) and P-values derived from likelihood ratio test for …
An additional denaturation step with 2 N chloridric acid for 30 min, and neutralization in PBS …

[PDF][PDF] Mutually exclusive CBC-containing complexes contribute to RNA fate

…, M Domanski, MC Robert, N Meola… - Cell reports, 2017 - cell.com
… A construct harboring CBP20 fused at its N terminus to the firefly luciferase (FFL) protein and
3xFLAG (3xFLAGFFL-CBP20) was transfected into HEK293T cells together with a construct …

Principles for RNA metabolism and alternative transcription initiation within closely spaced promoters

Y Chen, AA Pai, J Herudek, M Lubas, N Meola… - Nature …, 2016 - nature.com
… To define candidate cases, CAGE-defined mRNA TSSs (n = 14,788), that harbored a
downstream TSS within 2 kb from the pooled CAGE set (n = 37,299), producing convergent RNA, …

[PDF][PDF] A two-layered targeting mechanism underlies nuclear RNA sorting by the human exosome

G Wu, M Schmid, L Rib, P Polak, N Meola, A Sandelin… - Cell Reports, 2020 - cell.com
… proposed to target primarily longer polyadenylated transcripts (Meola et al., 2016). However,
… findings that NEXT targets are overall less abundant and mature than PAXT targets (Meola

[HTML][HTML] A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism

…, E Schmidt, BD Larsen, P Klemm, N Meola… - Nature …, 2020 - nature.com
Obesity and type 2 diabetes mellitus are global emergencies and long noncoding RNAs (lncRNAs)
are regulatory transcripts with elusive functions in metabolism. Here we show that a …

[HTML][HTML] MiR-211 is essential for adult cone photoreceptor maintenance and visual function

…, S Asteriti, F Naso, D Falanga, RS Bhat, N Meola… - Scientific reports, 2017 - nature.com
MicroRNAs (miRNAs) are key post-transcriptional regulators of gene expression that play an
important role in the control of fundamental biological processes in both physiological and …

[HTML][HTML] The ADAMTS18 gene is responsible for autosomal recessive early onset severe retinal dystrophy

…, M Pizzo, RWJ Collin, N Meola… - Orphanet journal of rare …, 2013 - Springer
… We carried out this test in st40 olAdamts18 knockdown embryos and we analyzed their
retinas 5 days later (post-hatching stage, n = 20 eyes). We observed a notable increase of light-…