[HTML][HTML] microRNAs and genetic diseases
N Meola, VA Gennarino, S Banfi - Pathogenetics, 2009 - Springer
microRNAs (miRNAs) are a class of small RNAs (19-25 nucleotides in length) processed from
double-stranded hairpin precursors. They negatively regulate gene expression in animals, …
double-stranded hairpin precursors. They negatively regulate gene expression in animals, …
[PDF][PDF] Identification of a nuclear exosome decay pathway for processed transcripts
N Meola, M Domanski, E Karadoulama, Y Chen… - Molecular cell, 2016 - cell.com
… For statistical analysis, all data are displayed as mean values with error bars denoting
SDs (n = 3 biological replicates). In (C) and (D), asterisks indicate detection of proteins of …
SDs (n = 3 biological replicates). In (C) and (D), asterisks indicate detection of proteins of …
MicroRNA target prediction by expression analysis of host genes
…, M Sardiello, R Avellino, N Meola… - Genome …, 2009 - genome.cshlp.org
… These genes had previously been validated as targets of 20 different intragenic miRNAs
either at the mRNA (n = 34) or at the translational (n = 22) level (Supplemental Table S1). We …
either at the mRNA (n = 34) or at the translational (n = 22) level (Supplemental Table S1). We …
The long noncoding RNA Vax2os1 controls the cell cycle progression of photoreceptor progenitors in the mouse retina
N Meola, M Pizzo, G Alfano, EM Surace, S Banfi - Rna, 2012 - rnajournal.cshlp.org
… (J–L) Values are means ± SEM (n = 4) and P-values derived from likelihood ratio test for …
An additional denaturation step with 2 N chloridric acid for 30 min, and neutralization in PBS …
An additional denaturation step with 2 N chloridric acid for 30 min, and neutralization in PBS …
[PDF][PDF] Mutually exclusive CBC-containing complexes contribute to RNA fate
…, M Domanski, MC Robert, N Meola… - Cell reports, 2017 - cell.com
… A construct harboring CBP20 fused at its N terminus to the firefly luciferase (FFL) protein and
3xFLAG (3xFLAGFFL-CBP20) was transfected into HEK293T cells together with a construct …
3xFLAG (3xFLAGFFL-CBP20) was transfected into HEK293T cells together with a construct …
Principles for RNA metabolism and alternative transcription initiation within closely spaced promoters
… To define candidate cases, CAGE-defined mRNA TSSs (n = 14,788), that harbored a
downstream TSS within 2 kb from the pooled CAGE set (n = 37,299), producing convergent RNA, …
downstream TSS within 2 kb from the pooled CAGE set (n = 37,299), producing convergent RNA, …
[PDF][PDF] A two-layered targeting mechanism underlies nuclear RNA sorting by the human exosome
… proposed to target primarily longer polyadenylated transcripts (Meola et al., 2016). However,
… findings that NEXT targets are overall less abundant and mature than PAXT targets (Meola …
… findings that NEXT targets are overall less abundant and mature than PAXT targets (Meola …
[HTML][HTML] A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism
Obesity and type 2 diabetes mellitus are global emergencies and long noncoding RNAs (lncRNAs)
are regulatory transcripts with elusive functions in metabolism. Here we show that a …
are regulatory transcripts with elusive functions in metabolism. Here we show that a …
[HTML][HTML] MiR-211 is essential for adult cone photoreceptor maintenance and visual function
…, S Asteriti, F Naso, D Falanga, RS Bhat, N Meola… - Scientific reports, 2017 - nature.com
MicroRNAs (miRNAs) are key post-transcriptional regulators of gene expression that play an
important role in the control of fundamental biological processes in both physiological and …
important role in the control of fundamental biological processes in both physiological and …
[HTML][HTML] The ADAMTS18 gene is responsible for autosomal recessive early onset severe retinal dystrophy
…, M Pizzo, RWJ Collin, N Meola… - Orphanet journal of rare …, 2013 - Springer
… We carried out this test in st40 olAdamts18 knockdown embryos and we analyzed their
retinas 5 days later (post-hatching stage, n = 20 eyes). We observed a notable increase of light-…
retinas 5 days later (post-hatching stage, n = 20 eyes). We observed a notable increase of light-…