Der Beteiligung von Bürgern und zivilgesellschaftlichen Akteuren an politisch-administrativen
Entscheidungsprozessen jenseits von Wahlen und Referenden wird vielfach ein hohes …

Ependymomas are common childhood brain tumours that occur throughout the nervous
system, but are most common in the paediatric hindbrain. Current standard therapy comprises …

All cancers are caused by somatic mutations; however, understanding of the biological
processes generating these mutations is limited. The catalogue of somatic mutations from a …

… Together, our study reveals the alteration of WNT, hedgehog, histone methyltransferase and
now N-CoR pathways across medulloblastomas and within specific subtypes of this disease…

… Restricting our analysis to Group 3 and Group 4 (n = 740) separated the parental subgroups
into up to eight subtypes (Fig. 4a, b). Iterative down-sampling performed on the same …

… hundred and eighty-four glioma samples from all grades and histological diagnoses across
the entire age range in this study were obtained from collaborators across Europe and North …

… The remainder were predicted to disrupt indirectly either the positive charge on the RNA-binding
surface (n = 2) or the folding of the closed form (n = 2). No truncating mutations were …

… To understand the mechanism(s) of primary resistance and identify pathways cooperating
with aberrant SHH signaling, we sequenced and profiled a large cohort of SHH-MBs (n = 133). …

… Here we describe whole-genome sequencing of 96 pilocytic astrocytomas, with matched
RNA sequencing (n = 73), conducted by the International Cancer Genome Consortium (ICGC) …

Genomic rearrangements are thought to occur progressively during tumor development.
Recent findings, however, suggest an alternative mechanism, involving massive chromosome …