Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as
BRCA1, and many common, mostly non-coding variants. However, much of the genetic …

… The median follow-up of those who did not die of breast cancer was 9.35 years (n = 186;
overall follow-up was 7.93 years, n = 247). Ten-year survival curves were estimated using the …

Background Germline truncating mutations in DICER1, an endoribonuclease in the RNase
III family that is essential for processing microRNAs, have been observed in families with the …

BACKGROUND: Approximately 2.0%-2.5% of Ashkenazi Jewish women carry one of three
founding mutations in the BRCA1 and BRCA2 genes, and each mutation is associated with a …

… = 12) clearly showed that the only recurrent LOH in SCCOHT samples (n = 8) occurred on
… non-SCCOHT samples (n = 3) and the matched blood sample of the SCCOHT case (n = 1). …

… Nucleotides labeled with N indicate sites where dual peaks are present. … University Health
Centre (Drs Rio Frio and Foulkes and Ms Hamel); Segal Cancer Centre, Lady Davis Institute, …

No more than ≈30% of hereditary breast cancer has been accounted for by mutations in
known genes. Most of these genes, such as BRCA1, BRCA2, TP53, CHEK2, ATM, and FANCJ/…

Prostate cancer has a strong familial component but uncovering the molecular basis for
inherited susceptibility for this disease has been challenging. Recently, a rare, recurrent …

Both the risk and the rate of development of atherosclerosis are increased in diabetics, but
the mechanisms involved are unknown. Here we report a glucose-mediated increase in …

… The resulting residue was treated with 1 N NaOH, extracted with ether (3 X 50 mL), and
acidified to pH 2 with concentrated HC1. Reextraction with ether (3 X 50 mL), drying (MgS04), …