… We found no notable difference in the IUPM values when using these two different
approaches with rCD4 + T cells isolated from three different participants with HIV-1 infection (…

Viral evolutionary pathways are determined by the fitness landscape, which maps viral
genotype to fitness. However, a quantitative description of the landscape and the evolutionary …

… To our knowledge, no natural recombinants in the region of the genome encoding VPg or
protease have been described. Previous analyses of naturally isolated MNV strains describe …

New human norovirus strains emerge every 2 to 3 years, partly due to mutations in the viral
capsid that allow escape from antibody neutralization and herd immunity. To understand how …

Signaling pathways play a key role in HIV-1 latency. In this study, we used the 24ST1NLESG
cell line of HIV-1 latency to screen a library of structurally diverse, medicinally active, cell …

Polyomaviruses encode a large T Ag (LT), a multifunctional protein essential for the regulation
of both viral and host cell gene expression and productive viral infection. Previously, we …

… The funders had no role in study design, data collection and analysis, decision to publish,
or … However, these viruses also occasionally integrate into the host genome, despite no …

Ectopic expression of Simian Virus 40 (SV40) large T antigen (LT) in mouse embryonic
fibroblasts (MEFs) increased levels of mRNAs encoding interferon stimulated genes (ISGs). The …

There is great enthusiasm toward the development of novel immunotherapies for the treatment
of cancer, and given their roles in immune system regulation, chemokines stand out as …

Rilpivirine (RPV), dapivirine (DPV), and MIV-150 are in development as microbicides. It is not
known whether they will block infection of circulating nonnucleoside reverse transcriptase …