The inherent capacity of somatic cells to switch their phenotypic status in response to damage
stimuli in vivo might have a pivotal role in ageing and cancer. However, how the entry-exit …

… Núria Folguera-Blasco and Tomás Alarcón acknowledge MINECO for funding under grant
MTM2015-71509-C2-1-R and AGAUR for funding under grant 2014 SGR1307. The authors …

Understanding the control of epigenetic regulation is key to explain and modify the aging
process. Because histone-modifying enzymes are sensitive to shifts in availability of cofactors (…

The geroncogenesis hypothesis postulates that the decline in metabolic cellular health that
occurs naturally with aging drives a “field effect” predisposing normal tissues for cancer …

Therapeutic strategies targeting the hallmarks of aging can be broadly grouped into four
categories, namely systemic (blood) factors, metabolic manipulation (diet regimens and dietary …

The inherent capacity of somatic cells to switch their phenotypic status in response to damage
stimuli in vivo might have a pivotal role in ageing and cancer. However, how the entry-exit …

Therapeutic strategies targeting the hallmarks of aging can be broadly grouped into four
categories, namely systemic (blood) factors, metabolic manipulation (diet regimens and dietary …

Standard of care for multiple myeloma involves au-tologous hematopoietic cell transplant (AHCT),
which can extend life by a year; however the disease remains incurable. A dendritic …

In this appendix, we present supplementary materials regarding the methods of our
manuscript Epigenetic regulation of cell fate reprogramming in aging and disease: A predictive …

… Author links open overlay panel Mercè Folguera Blasco a , Bernat de Pablo Márquez a b
, … N Engl J Med., 350 (18) (2004), pp. 1819-1827 … Paterson, N. Scott, A. Hair, PJ O'Dwyer …