User profiles for N. Desch

A Nicole Desch

Johnson & Johnson
Verified email at broadinstitute.org
Cited by 2504

Tetrahedral robotics for space exploration

…, C Cooperider, M Desch, N Desch… - 2007 IEEE …, 2007 - ieeexplore.ieee.org
A reconfigurable space filling robotic architecture has a wide range of possible applications.
One of the more intriguing possibilities is mobility in very irregular and otherwise …

[PDF][PDF] Intra-and inter-cellular rewiring of the human colon during ulcerative colitis

…, O Rozenblatt-Rosen, JJ Garber, H Khalili, AN Desch… - Cell, 2019 - cell.com
Genome-wide association studies (GWAS) have revealed risk alleles for ulcerative colitis (UC).
To understand their cell type specificities and pathways of action, we generate an atlas of …

[HTML][HTML] Life cycle assessment of various PMSG-based drivetrain concepts for 15 MW offshore wind turbines applications

FK Moghadam, N Desch - Energies, 2023 - mdpi.com
… f 1 t o r − n o n r i g i d = 1 2 π α 2 k r k g e n k r + α 2 k g e n J r + α 2 J g e n α 2 J r J g e n , …
Gear-ratio in IEC 61400-4 is defined by n n r , where n and n r are the rotational speeds of the …

Three unique interstitial macrophages in the murine lung at steady state

…, SM Atif, AL McCubbrey, AN Desch… - American journal of …, 2017 - atsjournals.org
… Data are representative of four independent experiments with n = 3. (C) Histograms display
overlays of all three IMs for the expression of CD11c, CX 3 CR1 (reported), and CCR2 from …

Pulmonary dendritic cell development and antigen acquisition

AN Desch, PM Henson, CV Jakubzick - Immunologic research, 2013 - Springer
Pulmonary dendritic cells (DCs) constantly sample the tissue and traffic inhaled antigens to
the lung-draining lymph node where they normally orchestrate an appropriate immune …

CD103+ pulmonary dendritic cells preferentially acquire and present apoptotic cell–associated antigen

AN Desch, GJ Randolph, K Murphy… - Journal of Experimental …, 2011 - rupress.org
Cells undergoing programmed cell death (apoptosis) are removed in situ by macrophages
and dendritic cells (DCs) through a specialized form of phagocytosis (efferocytosis). In the …

Transcriptome analysis highlights the conserved difference between embryonic and postnatal-derived alveolar macrophages

SL Gibbings, R Goyal, AN Desch… - Blood, The Journal …, 2015 - ashpublications.org
Alveolar macrophages (AMs) reside on the luminal surfaces of the airways and alveoli
where they maintain host defense and promote alveolar homeostasis by ingesting inhaled …

Flow cytometric analysis of mononuclear phagocytes in nondiseased human lung and lung-draining lymph nodes

AN Desch, SL Gibbings, R Goyal, R Kolde… - American journal of …, 2016 - atsjournals.org
Rationale: The pulmonary mononuclear phagocyte system is a critical host defense mechanism
composed of macrophages, monocytes, monocyte-derived cells, and dendritic cells. …

[HTML][HTML] Dendritic cell subsets require cis-activation for cytotoxic CD8 T-cell induction

AN Desch, SL Gibbings, ET Clambey… - Nature …, 2014 - nature.com
Dendritic cells (DCs) are required for the induction of cytotoxic T cells (CTL). In most tissues,
including the lung, the resident DCs fall into two types expressing the integrin markers …

C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions

V Mohanan, T Nakata, AN Desch, C Lévesque… - Science, 2018 - science.org
… Domain-mapping experiments further indicated that the N-terminal domain of C1orf106
interacts specifically with the N-terminal domain of cytohesin-1 (Fig. 1, C and E). …