Pancreatic cancer remains one of the most lethal of malignancies and a major health burden.
We performed whole-genome sequencing and copy number variation (CNV) analysis of …

Integrated genomic analysis of 456 pancreatic ductal adenocarcinomas identified 32 recurrently
mutated genes that aggregate into 10 pathways: KRAS, TGF-β, WNT, NOTCH, ROBO/…

Pancreatic cancer is a highly lethal malignancy with few effective therapies. We performed
exome sequencing and copy number analysis to define genomic aberrations in a …

Despite a library full of literature on miRNA biology, core issues relating to miRNA target
detection, biological effect, and mode of action remain controversial. This essay proposes that …

Massively parallel short-tag sequencing of cDNA libraries-RNAseq-is being used to study
the dynamics and complexity of eukaryotic transcriptomes, giving new biological insights …

We developed a massive-scale RNA sequencing protocol, short quantitative random RNA
libraries or SQRL, to survey the complexity, dynamics and sequence content of transcriptomes …

Although repetitive elements pervade mammalian genomes, their overall contribution to
transcriptional activity is poorly defined. Here, as part of the FANTOM4 project, we report that 6–…

Upregulation of the immune response may be involved in the pathogenesis of schizophrenia
with changes occurring in both peripheral blood and brain tissue. To date, microarray …

Background Variants of microRNAs (miRNAs), called isomiRs, are commonly reported in
deep-sequencing studies; however, the functional significance of these variants remains …

… Nicole Cloonan, BSc Nicole Cloonan … N Cloonen helped to plan and coordinate the study,
extracted DNA from the volunteers' blood samples, and did all the original diagnostic PCRs. …