Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical, …

Oxidative stress refers to elevated intracellular levels of reactive oxygen species (ROS) that
cause damage to lipids, proteins and DNA. Oxidative stress has been linked to a myriad of …

‘Reactive oxygen species’ (ROS) is a generic term that defines a wide variety of oxidant
molecules with vastly different properties and biological functions that range from signalling to …

… Yet we have found N-MPG to be effective at concentrations of 200 μM. To test the … N-MPG
at 5 mM may directly reduce O 2 (data not shown). We suggest that high concentrations of N-…

Tumour initiation and progression requires the metabolic reprogramming of cancer cells.
Cancer cells autonomously alter their flux through various metabolic pathways in order to meet …

Historically, mitochondrial reactive oxygen species (mROS) were thought to exclusively
cause cellular damage and lack a physiological function. Accumulation of ROS and oxidative …

Tumors reprogram pathways of nutrient acquisition and metabolism to meet the bioenergetic,
biosynthetic, and redox demands of malignant cells. These reprogrammed activities are …

… = 4; mean ± SD D, HIF-1α protein in Hep3B cells exposed to 21% O 2 and 10 μm N-carbobenzoxyl-l-leucinyl-l-leucinyl-l-norvalinal
in the presence calyculin A (5 nm) or wortmannin (…

Otto Warburg's theory on the origins of cancer postulates that tumor cells have defects in
mitochondrial oxidative phosphorylation and therefore rely on high levels of aerobic glycolysis …

Mitochondrial physiology is disrupted in either apoptosis or necrosis. Here, we report that a
wide variety of apoptotic and necrotic stimuli induce progressive mitochondrial swelling and …