After the discovery of NPM1-mutated acute myeloid leukemia (AML) in 2005 and its subsequent
inclusion as a provisional entity in the 2008 World Health Organization classification of …

… One is found within residues 94–102 with the sequence I-xx-P-xx-L-x-L 13 and the other at
the N-terminus within amino acids 42 to 49 (sequence L-x-L-xx-V-x-L), with leucines 42 and …

… In the encoded NPM-MLF1 fusion protein, the N-terminal portion of NPM is fused to almost
the entire MLF1 protein, excluding only the first 16 amino acids at the N-terminus96 (Figure 1B…

All cancers are caused by somatic mutations; however, understanding of the biological
processes generating these mutations is limited. The catalogue of somatic mutations from a …

Background Recent studies have provided a detailed census of genes that are mutated in
acute myeloid leukemia (AML). Our next challenge is to understand how this genetic diversity …

… Two (n=13) or three (n=2) serial samples were available for 15 patients. Fifteen patients were
sampled … The fraction of cells bearing each mutation was then calculated as n mut /n chr . …

Introduction The human genome is peppered with mobile repetitive elements called long
interspersed nuclear element–1 (L1) retrotransposons. Propagating through RNA and cDNA …

… n = 784 dataset, since for this analysis, presence of ISS was not required. c OS in the same
set of patients (n = 863) … Note that this dataset is larger than the n = 784 dataset, since for this …

… n = 49); mutations in the metastasis not found in the primary (n = 49); and shared mutations
(n … drift (VAF difference >0.2) between the two samples (n = 25). These data, particularly the …

Understanding the profile of oncogene and tumor suppressor gene mutations with their
interactions and impact on the prognosis of multiple myeloma (MM) can improve the definition of …