Interventional pharmacology is one of medicine's most potent weapons against disease.
These drugs, however, can result in damaging side effects and must be closely monitored. …

A more nuanced approach to drug design is to use multiple drugs in combination to target
interacting or complementary pathways. Drug combination treatments have shown higher …

… for NP drug discovery. These methods are summarized graphically in Figure 1. Finally, we
conclude with a recap of the major gaps currently facing the field of computational NP drug …

10.7554/eLife.02523.001 Exchange of extracellular cystine for intracellular glutamate by the
antiporter system x c − is implicated in numerous pathologies. Pharmacological agents that …

… To address this problem of omission and improve the ability to analyze drug effects, Tatonetti
et al. use an adaptive data-driven approach to correct for the lack of such information—the …

The rapid global spread of the novel coronavirus SARS-CoV-2 has strained healthcare and
testing resources, making the identification and prioritization of individuals most at-risk a …

… We leveraged whole-genome RNA sequencing (RNA-seq) profiles to identify
differentially regulated genes and pathways in 650 NP swabs from control and SARS-CoV-2-infected …

Adverse drug events cause substantial morbidity and mortality and are often discovered after
a drug comes to market. We hypothesized that Internet users may provide early clues about …

The lipid‐lowering agent pravastatin and the antidepressant paroxetine are among the most
widely prescribed drugs in the world. Unexpected interactions between them could have …

Objective Adverse drug events (ADEs) are common and account for 770 000 injuries and
deaths each year and drug interactions account for as much as 30% of these ADEs. …