Characterized by the accumulation of somatic mutations in blood cell lineages, clonal
hematopoiesis of indeterminate potential (CHIP) is frequent in aging and involves the expansion of …

Background Triple-negative breast cancer (TNBC) constitutes 10–20% of breast cancers
and is challenging to treat due to a lack of effective targeted therapies. Previous studies in …

Hypertension is a threatening chronic disease, which become a global killer among the
adult population. The mortality rate increasing day by day even several Angiotensin I-converting …

We conducted a multiinstitutional, placebo-controlled phase IIB trial of the lignan secoisolariciresinol
diglucoside (SDG) found in flaxseed. Benign breast tissue was acquired by random …

Cancer cell proliferation is a high energy demanding process, where the cancer cells acquire
energy by high rates of glycolysis, and this phenomenon is known as the “Warburg effect”. …

We examined the impact of an APOE ε4 genotype on Alzheimer's disease (AD) subject
platelet and lymphocyte metabolism. Mean platelet mitochondrial cytochrome oxidase Vmax …

Although Microrchidia 2 (MORC2) is widely overexpressed in human malignancies and
linked to cancer cell proliferation, metabolism, and metastasis, the mechanism of action of …

Darunavir is a synthetic nonpeptidic protease inhibitor which has been tested for anticancer
properties. To deduce and enhance the anticancer activity of the Darunavir, we have …

There are enormous evidences and previous reports standpoint that the enzyme of glyoxylate
pathway malate synthase G (MSG) is a potential virulence factor in several pathogenic …

Inhibition of 11β-HSD1 enzymatic action is perceived as a potential target for the treatment
of metabolic syndromes like cardiovascular diseases, obesity, and diabetes. In an attempt to …