A synthetic lethal interaction occurs between two genes when the perturbation of either
gene alone is viable but the perturbation of both genes simultaneously results in the loss of …

We have previously shown that ASPP1 and ASPP2 are specific activators of p53; one
mechanism by which wild-type p53 is tolerated in human breast carcinomas is through loss of …

G-quadruplex DNAs form four-stranded helical structures and are proposed to play key roles
in different cellular processes. Targeting G-quadruplex DNAs for cancer treatment is a very …

Homologous recombination (HR) is an important conserved process for DNA repair and
ensures maintenance of genome integrity. Inappropriate HR causes gross chromosomal …

Endometrial cancer is the sixth most commonly diagnosed cancer in women worldwide,
causing ∼74,000 deaths annually 1 . Serous endometrial cancers are a clinically aggressive …

… (NJ O'Neil, unpubl.). However, the complex nature of the mutation hindered attempts to
determine the exact structure of the rearrangement. ruIs32 is a low-copy-number insertion that …

Cohesins are mutated in a significant number of tumors of various types making them attractive
targets for chemotherapeutic intervention. However, cohesins have a spectrum of cellular …

Recent data have identified STAG2, a core subunit of the multifunctional cohesin complex,
as a highly recurrently mutated gene in several types of cancer. We sought to identify a …

Synthetic lethality has been proposed as a way to leverage the genetic differences found in
tumor cells to affect their selective killing. Cohesins, which tether sister chromatids together …

Fanconi anemia (FA) is a cancer susceptibility syndrome characterized by defective DNA
interstrand cross-link (ICL) repair. Here, we show that DOG-1 is the Caenorhabditis elegans …