TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndrome
NJ Lambacher, AL Bruel, TJP Van Dam… - Nature cell …, 2016 - nature.com
The transition zone (TZ) ciliary subcompartment is thought to control cilium composition and
signalling by facilitating a protein diffusion barrier at the ciliary base. TZ defects cause …
signalling by facilitating a protein diffusion barrier at the ciliary base. TZ defects cause …
[HTML][HTML] CiliaCarta: An integrated and validated compendium of ciliary genes
…, KA Wunderlich, S Rix, GW Dougherty, NJ Lambacher… - PloS one, 2019 - journals.plos.org
The cilium is an essential organelle at the surface of mammalian cells whose dysfunction
causes a wide range of genetic diseases collectively called ciliopathies. The current rate at …
causes a wide range of genetic diseases collectively called ciliopathies. The current rate at …
[HTML][HTML] KIAA0556 is a novel ciliary basal body component mutated in Joubert syndrome
…, A Alhashem, B Tabarki, Q Lu, NJ Lambacher… - Genome biology, 2015 - Springer
Background Joubert syndrome (JBTS) and related disorders are defined by cerebellar
malformation (molar tooth sign), together with neurological symptoms of variable expressivity. The …
malformation (molar tooth sign), together with neurological symptoms of variable expressivity. The …
[HTML][HTML] The inner junction protein CFAP20 functions in motile and non-motile cilia and is critical for vision
PW Chrystal, NJ Lambacher, LP Doucette… - Nature …, 2022 - nature.com
Motile and non-motile cilia are associated with mutually-exclusive genetic disorders. Motile
cilia propel sperm or extracellular fluids, and their dysfunction causes primary ciliary …
cilia propel sperm or extracellular fluids, and their dysfunction causes primary ciliary …
Role for intraflagellar transport in building a functional transition zone
Genetic disorders caused by cilia dysfunction, termed ciliopathies, frequently involve the
intraflagellar transport ( IFT ) system. Mutations in IFT subunits—including IFT ‐dynein motor …
intraflagellar transport ( IFT ) system. Mutations in IFT subunits—including IFT ‐dynein motor …
Caenorhabditis elegans telomere-binding proteins TEBP-1 and TEBP-2 adapt the Myb module to dimerize and bind telomeric DNA
S Padmanaban, NJ Lambacher… - Proceedings of the …, 2024 - National Acad Sciences
Protecting chromosome ends from misrecognition as double-stranded (ds) DNA breaks is
fundamental to eukaryotic viability. The protein complex shelterin prevents a DNA damage …
fundamental to eukaryotic viability. The protein complex shelterin prevents a DNA damage …
Primary Cilium Formation and Ciliary Protein Trafficking Is Regulated by the Atypical MAP Kinase MAPK15 in Caenorhabditis elegans and Human Cells
A Kazatskaya, S Kuhns, NJ Lambacher, JE Kennedy… - Genetics, 2017 - academic.oup.com
… Nils J Lambacher , Nils J Lambacher … Anna Kazatskaya, Stefanie Kuhns, Nils J Lambacher,
Julie E Kennedy, Andrea G Brear, Gavin J McManus, Piali Sengupta, Oliver E Blacque, …
Julie E Kennedy, Andrea G Brear, Gavin J McManus, Piali Sengupta, Oliver E Blacque, …
Fluorescence interference-contrast microscopy on oxidized silicon using a monomolecular dye layer
A Lambacher, P Fromherz - Applied Physics A, 1996 - Springer
… The Fresnel coefficients of reflection and transmission at an interface between media of
refractive index n, and nj as a function of the angles 0~ and 0j with respect to the normal in those …
refractive index n, and nj as a function of the angles 0~ and 0j with respect to the normal in those …
SUGGESTED SEARCHES
…, BP Pedersen, S Padmanaban, NJ Lambacher… - …, 2024 - National Acad Sciences
Trending Articles | PNAS PNAS Logo PNAS Logo ARTICLES Current IssueLatest ArticlesSpecial
FeaturesList of IssuesPNAS Nexus Front Matter AUTHORS Information for AuthorsEditorial and …
FeaturesList of IssuesPNAS Nexus Front Matter AUTHORS Information for AuthorsEditorial and …
Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin
…, E Rognoni, M Veelders, M Bharadwaj, A Lambacher… - Elife, 2016 - elifesciences.org
10.7554/eLife.10130.001 Integrins require an activation step prior to ligand binding and
signaling. How talin and kindlin contribute to these events in non-hematopoietic cells is poorly …
signaling. How talin and kindlin contribute to these events in non-hematopoietic cells is poorly …