User profiles for N. H. Shirole
 | Nitin H. ShiroleHope Funds Sakonnet Fellow, Dana Farber Cancer Institute/ Harvard Medical School Verified email at dfci.harvard.edu Cited by 711 |
[PDF][PDF] SRSF1-regulated alternative splicing in breast cancer
Splicing factor SRSF1 is upregulated in human breast tumors, and its overexpression
promotes transformation of mammary cells. Using RNA-seq, we identified SRSF1-regulated …
promotes transformation of mammary cells. Using RNA-seq, we identified SRSF1-regulated …
[HTML][HTML] Rapid and tunable method to temporally control gene editing based on conditional Cas9 stabilization
The CRISPR/Cas9 system is a powerful tool for studying gene function. Here, we describe a
method that allows temporal control of CRISPR/Cas9 activity based on conditional Cas9 …
method that allows temporal control of CRISPR/Cas9 activity based on conditional Cas9 …
von-Hippel Lindau and hypoxia-inducible factor at the center of renal cell carcinoma biology
NH Shirole, WG Kaelin - Hematology/Oncology Clinics, 2023 - hemonc.theclinics.com
Kidney cancer is one of the 10 most common cancers in the developed world and is increasing
in incidence. In 2020 there were more than 400,000 new cases of kidney cancer and …
in incidence. In 2020 there were more than 400,000 new cases of kidney cancer and …
TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions
10.7554/eLife.17929.001 TP53 truncating mutations are common in human tumors and are
thought to give rise to p53-null alleles. Here, we show that TP53 exon-6 truncating mutations …
thought to give rise to p53-null alleles. Here, we show that TP53 exon-6 truncating mutations …
TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24− cancer cells
10.7554/eLife.21615.001 Many lines of evidence have indicated that both genetic and non-genetic
determinants can contribute to intra-tumor heterogeneity and influence cancer …
determinants can contribute to intra-tumor heterogeneity and influence cancer …
Crucial elements that maintain the interactions between the regulatory TnaC peptide and the ribosome exit tunnel responsible for Trp inhibition of ribosome function
AK Martínez, NH Shirole, S Murakami… - Nucleic acids …, 2012 - academic.oup.com
Translation of the TnaC nascent peptide inhibits ribosomal activity in the presence of l-tryptophan,
inducing expression of the tnaCAB operon in Escherichia coli. Using chemical …
inducing expression of the tnaCAB operon in Escherichia coli. Using chemical …
Correction: TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions
Shirole NH, Pal D, Kastenhuber ER, Senturk S, Boroda J, Pisterzi P, Miller M, Munoz G,
Anderluh M, Ladanyi M, Lowe SW, Sordella R. 2016. TP53 exon-6 truncating mutations produce …
Anderluh M, Ladanyi M, Lowe SW, Sordella R. 2016. TP53 exon-6 truncating mutations produce …
A rapid and tunable method to temporally control Cas9 expression enables the identification of essential genes and the interrogation of functional gene interactions in …
The Cas9/CRISPR system is a powerful tool for studying gene function. Here we describe a
method that allows temporal control of Cas9/CRISPER activity based on conditional Cas9 …
method that allows temporal control of Cas9/CRISPER activity based on conditional Cas9 …
Abstract PR011: Downregulation of the HIF2a target cyclin D1 underlies the efficacy of the HIF2a inhibitor belzutifan in kidney cancer
NH Shirole, D Kesar, WR Sellers, WG Kaelin Jr - Cancer Research, 2023 - AACR
Abstract: Most clear cell renal cell carcinomas (ccRCCs) are caused by loss of the pVHL
tumor suppressor function. Inactivation of pVHL leads to increased accumulation of HIF2a, …
tumor suppressor function. Inactivation of pVHL leads to increased accumulation of HIF2a, …
22 Inducible CRISPR-based Genome Editing for the Characterization of Cancer Genes
Recent advances in sequencing technology have enabled us to study the molecular
alterations in tumors to an unprecedented degree of granularity. At the same time, CRISPR/Cas9 …
alterations in tumors to an unprecedented degree of granularity. At the same time, CRISPR/Cas9 …