Initial expectations for genome-wide association studies were high, as such studies promised
to rapidly transform personalized medicine with individualized disease risk predictions, …

Background Aspirin-exacerbated respiratory disease (AERD) is manifested by adult-onset
asthma, nasal polyposis, chronic rhinosinusitis, and aspirin sensitivity. Previously reported …

Background Acute infections can cause an individual to have an elevated resting heart rate (RHR)
and change their routine daily activities due to the physiological response to the …

Background/objectives Physical activity (PA) protects against a wide range of diseases.
Habitual PA appears to be heritable, motivating the search for specific genetic variants that may …

Structural variations are among the most frequent interindividual genetic differences in the
human genome. The frequency and distribution of de novo somatic structural variants in …

Studies of long-lived individuals have revealed few genetic mechanisms for protection
against age-associated disease. Therefore, we pursued genome sequencing of a related …

Background Active engagement in the management of hypertension is important in improving
self-management behaviors and clinical outcomes. Mobile phone technology using …

Background There are few empirical data to inform the debate surrounding the use and
regulation of direct-to-consumer (DTC) genome-wide disease risk tests. This study aimed to …

Background. Mobile health and digital medicine technologies are becoming increasingly used
by individuals with common, chronic diseases to monitor their health. Numerous devices, …

Rheumatoid arthritis (RA) affects millions world-wide. While anti-TNF treatment is widely
used to reduce disease progression, treatment fails in ∼one-third of patients. No biomarker …