Whole-genome sequencing of antimicrobial-resistant pathogens is increasingly being used
for antimicrobial resistance (AMR) surveillance, particularly in high-income countries. …

Nearly a century after the beginning of the antibiotic era, which has been associated with
unparalleled improvements in human health and reductions in mortality associated with …

A core question in evolutionary biology is whether convergent phenotypic evolution is
driven by convergent molecular changes in proteins or regulatory regions. We combined …

Highlights • The predictive brain construes the world as consistent with top-down predictions,
while minimizing error in predictions. • Individuals are motivated to minimize prediction …

… Typhimurium sequences included in this study, grouped into lineage, as calculated by the
method of Wheeler et al. . Summary of statistics on different clades: Non-ST313: median = …

Discovery of genetic variants underlying bacterial phenotypes and the prediction of phenotypes
such as antibiotic resistance are fundamental tasks in bacterial genomics. Genome-wide …

Background Klebsiella species, including the notable pathogen K. pneumoniae, are
increasingly associated with antimicrobial resistance (AMR). Genome-based surveillance can …

Streptococcus pneumoniae is a common nasopharyngeal colonizer, but can also cause life-threatening
invasive diseases such as empyema, bacteremia and meningitis. Genetic …

Emerging pathogens are a major threat to public health, however understanding how
pathogens adapt to new niches remains a challenge. New methods are urgently required to …

Neisseria gonorrhoeae is an urgent public health threat due to rapidly increasing incidence
and antibiotic resistance. In contrast with the trend of increasing resistance, clinical isolates …